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    Y71G12B.10 hydroxymethylglutaryl-CoA lyase [ Caenorhabditis elegans ]

    Gene ID: 171738, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Y71G12B.10
    Official Full Name
    hydroxymethylglutaryl-CoA lyase
    Primary source
    WormBase:WBGene00022150
    Locus tag
    CELE_Y71G12B.10
    See related
    AllianceGenome:WB:WBGene00022150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Used to study 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y71G12B.10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (1751481..1754410)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha Neighboring gene ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylglutaryl-CoA lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylglutaryl-CoA lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxo-acid-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ketone body biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA lyase
    NP_490889.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1751481..1754410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058488.6 → NP_490889.1  hydroxymethylglutaryl-CoA lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XN1
      Conserved Domains (1) summary
      cd07938
      Location:21 → 293
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    Nucleotide Protein
    Heading Accession and Version

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