U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    spd-2 Spindle-defective protein 2 [ Caenorhabditis elegans ]

    Gene ID: 172712, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spd-2
    Official Full Name
    Spindle-defective protein 2
    Primary source
    WormBase:WBGene00004953
    Locus tag
    CELE_F32H2.3
    See related
    AllianceGenome:WB:WBGene00004953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables molecular adaptor activity and protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Is expressed in germ line; gonad; and intestinal cell. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spd-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (8966985..8970081, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene snRNA-activating protein complex subunit 4 homolog Neighboring gene Mediator of RNA polymerase II transcription subunit 31 Neighboring gene Integrator complex subunit 1 R4 domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene SRCR domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A combined in silico and in vivo approach to the structure-function annotation of SPD-2 provides mechanistic insight into its functional diversity. Murph M, et al. Cell Cycle, 2022 Sep. PMID 35678569, Free PMC Article
    2. Limiting amounts of centrosome material set centrosome size in C. elegans embryos. Decker M, et al. Curr Biol, 2011 Aug 9. PMID 21802300
    3. An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos. Hara Y, et al. Mol Biol Cell, 2013 May. PMID 23468523, Free PMC Article
    4. Polo-like kinase 4 shapes up. Levine MS, et al. Structure, 2014 Aug 5. PMID 25099950
    5. Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans. Lu Y, et al. PLoS One, 2014. PMID 25360893, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome-templated microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Spindle-defective protein 2
    NP_492414.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8966985..8970081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060013.8 → NP_492414.1  Spindle-defective protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91870
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91870.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools