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    cfim-1 Cleavage and polyadenylation specificity factor subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 172657, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cfim-1
    Official Full Name
    Cleavage and polyadenylation specificity factor subunit 5
    Primary source
    WormBase:WBGene00009668
    Locus tag
    CELE_F43G9.5
    See related
    AllianceGenome:WB:WBGene00009668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in mRNA processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage factor complex. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Orthologous to human NUDT21 (nudix hydrolase 21). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cfim-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (8615388..8616420)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LysM domain-containing protein Neighboring gene PWWP domain-containing protein Neighboring gene Mitochondrial coenzyme A transporter SLC25A42 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene C2 domain-containing protein;Sperm vesicle fusion protein fer-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    3. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
    4. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
    5. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA cleavage factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage and polyadenylation specificity factor subunit 5
    NP_492334.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8615388..8616420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059933.4 → NP_492334.1  Cleavage and polyadenylation specificity factor subunit 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93716
      Conserved Domains (1) summary
      pfam13869
      Location:32 → 219
      NUDIX_2; Nucleotide hydrolase
    Nucleotide Protein
    Heading Accession and Version

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