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    edc-3 DFDF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172653, updated on 2-Nov-2024

    Summary

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    Official Symbol
    edc-3
    Official Full Name
    DFDF domain-containing protein
    Primary source
    WormBase:WBGene00011036
    Locus tag
    CELE_R05D11.8
    See related
    AllianceGenome:WB:WBGene00011036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in P-body assembly and deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be active in P-body. Is expressed in hypodermal cell; intestinal cell; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 50. Orthologous to human EDC3 (enhancer of mRNA decapping 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See edc-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (8602125..8605162)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative ATP-dependent RNA helicase DDX52 Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein Neighboring gene Vesicle transport protein Neighboring gene putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization. Vidya E, et al. Cell Rep, 2024 Oct 22. PMID 39331503
    2. Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans. Rieckher M, et al. Cell Rep, 2018 Oct 2. PMID 30282029, Free PMC Article
    3. Insight into the interaction between the RNA helicase CGH-1 and EDC-3 and its implications. Zhang Y, et al. Sci Rep, 2021 Oct 13. PMID 34645931, Free PMC Article
    4. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article
    5. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Garrido-Lecca A, et al. Mol Cell Biol, 2010 Aug. PMID 20498277, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.
      Title: EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DFDF domain-containing protein
    NP_492328.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8602125..8605162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059927.7 → NP_492328.1  DFDF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21740
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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