fsn-1 F-box/SPRY domain-containing protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fsn-1
Official Full Name: F-box/SPRY domain-containing protein 1
Primary source: WormBase:WBGene00001499
Locus tag: CELE_C26E6.5
See related: AllianceGenome:WB:WBGene00001499
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protease binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of neuron projection development; and positive regulation of neuromuscular synaptic transmission. Located in neuromuscular junction; neuron projection; and presynapse. Is expressed in neurons. Orthologous to human FBXO45 (F-box protein 45). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fsn-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (4937322..4939453)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

region of RPM-1 that is sufficient in binding to FSN-1
Title: Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex.
FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing.
Title: Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
Identification of FSN-1 as a negative regulator of cep-1-dependent germ cell apoptosis.
Title: The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans.
identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction and/or maturation of synapses in Caenorhabditis elegans
Title: An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C26E6.6 (e-PCR)
- UniSTS:308640

C26E6.5 (e-PCR)
- UniSTS:309153

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly involved in innervation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box/SPRY domain-containing protein 1

NP_498046.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4937322..4939453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065645.8 → NP_498046.1 F-box/SPRY domain-containing protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18223

Conserved Domains (2) summary

pfam00646
Location:83 → 127

F-box; F-box domain

cd12907
Location:158 → 332

SPRY_Fbox; SPRY domain in the F-box family Fbxo45