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    zhp-3 Zip homologous protein 3 [ Caenorhabditis elegans ]

    Gene ID: 172644, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zhp-3
    Official Full Name
    Zip homologous protein 3
    Primary source
    WormBase:WBGene00006976
    Locus tag
    CELE_K02B12.8
    See related
    AllianceGenome:WB:WBGene00006976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SUMO transferase activity. Involved in embryo development; meiotic chromosome segregation; and synaptonemal complex disassembly. Located in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See zhp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (8529376..8531342, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tonsoku-like protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Arf-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Guanine nucleotide-binding protein alpha-15 subunit Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutating two putative phosphorylation sites on ZHP-3 does not affect its localization or function during meiotic chromosome segregation. Russo AE, et al. MicroPubl Biol, 2021 Jan 18. PMID 33490887, Free PMC Article
    2. COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans. Yang Y, et al. Nucleic Acids Res, 2024 May 8. PMID 38412290, Free PMC Article
    3. COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers. Yokoo R, et al. Cell, 2012 Mar 30. PMID 22464324, Free PMC Article
    4. Synaptonemal Complex Central Region Proteins Promote Localization of Pro-crossover Factors to Recombination Events During Caenorhabditis elegans Meiosis. Cahoon CK, et al. Genetics, 2019 Oct. PMID 31431470, Free PMC Article
    5. C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata. Nguyen H, et al. PLoS Genet, 2018 Oct. PMID 30379819, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that CO-promoting factors MSH-4, MSH-5, and ZHP-3, but not COSA-1, are required for the apoptotic response of the meiotic DNA damage checkpoint.
      Title: Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.
    2. In meiotic prophase, Zph-3 shifts from along the length of the synaptonemal complex(SC) to an asymmetric localization on the SC and becomes restricted to foci that mark crossover recombination events.
      Title: ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptonemal complex disassembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptonemal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zip homologous protein 3
    NP_001250801.1
    • Confirmed by transcript evidence
    NP_001250802.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8529376..8531342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001263873.4 → NP_001250802.1  Zip homologous protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRL6, P90905
      Conserved Domains (1) summary
      cd16560
      Location:5 → 43
      RING-HC_RNF212_like; RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins

    2. NM_001263872.3 → NP_001250801.1  Zip homologous protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90905
      Conserved Domains (2) summary
      TIGR02168
      Location:67 → 163
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16560
      Location:5 → 43
      RING-HC_RNF212_like; RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C6KRL6.1

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