paxt-1 Partner of xrn-2 protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: paxt-1
Official Full Name: Partner of xrn-2 protein 1
Primary source: WormBase:WBGene00011034
Locus tag: CELE_R05D11.6
See related: AllianceGenome:WB:WBGene00011034
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in mRNA processing. Located in nucleolus and nucleoplasm. Is expressed in hypodermis. Orthologous to human CDKN2AIPNL (CDKN2A interacting protein N-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See paxt-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (8596333..8598551)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

De-repression appears to be triggered such that more robust XRN2 perturbation, by elimination of both PAXT-1 and BPNT1, is less detrimental to worm viability than absence of PAXT-1 alone. Indeed, we find that two distinct XRN2 repression mechanisms are alleviated at different thresholds of XRN2 inactivation. Like more than 15% of C. elegans genes, xrn-2 occurs in an operon, and we identify additional
Title: XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans.
In Caenorhabditis elegans, XRN-2 functions with PAXT-1, which shares a putative XRN-2-binding domain (XTBD) with otherwise unrelated mammalian proteins. The study characterizes the structure and function of an XTBD-XRN2 complex.
Title: Structural basis and function of XRN2 binding by XTB domains.
R05D11.6/PAXT-1 is a subunit of an XRN2 complex in C. elegans.
Title: PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05D11.6 (e-PCR)
- UniSTS:314746

R05D11.5 (e-PCR)
- UniSTS:312043

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Partner of xrn-2 protein 1

NP_001379143.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8596333..8598551

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392688.1 → NP_001379143.1 Partner of xrn-2 protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21738

Conserved Domains (1) summary

pfam11952
Location:7 → 91

XTBD; XRN-Two Binding Domain, XTBD