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    smc-5 Structural maintenance of chromosomes protein 5 [ Caenorhabditis elegans ]

    Gene ID: 173874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smc-5
    Official Full Name
    Structural maintenance of chromosomes protein 5
    Primary source
    WormBase:WBGene00016151
    Locus tag
    CELE_C27A2.1
    See related
    AllianceGenome:WB:WBGene00016151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded DNA binding activity. Involved in meiotic DNA double-strand break processing involved in reciprocal meiotic recombination. Located in condensed nuclear chromosome. Is expressed in germ line. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smc-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (5062125..5067129)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Lysosomal acid phosphatase Neighboring gene ncRNA Neighboring gene Protein sleepless Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability. Bickel JS, et al. PLoS Genet, 2010 Jul 22. PMID 20661436, Free PMC Article
    2. Salmonella enterica Serovar Typhi exposure elicits deliberate physiological alterations and triggers the involvement of ubiquitin mediated proteolysis pathway in Caenorhabditis elegans. Balasubramaniam B, et al. Int J Biol Macromol, 2020 Apr 15. PMID 31987945
    3. Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis. Odiba AS, et al. Genetics, 2023 Oct 4. PMID 37579186, Free PMC Article
    4. Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance. Jagut M, et al. PLoS Biol, 2016 Mar. PMID 27011106, Free PMC Article
    5. Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants. Wolters S, et al. Genetics, 2014 Apr. PMID 24424777, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results suggest that SMC-5/6 and HIM-6 can synergistically regulate recombination intermediate metabolism and suppress ectopic recombination by controlling chromosome architecture during meiosis.
      Title: The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
    2. Data propose that SMC-5/6 promotes replication fork stability and facilitates recombination-dependent repair.
      Title: Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes protein 5
    NP_494935.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5062125..5067129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062534.5 → NP_494935.1  Structural maintenance of chromosomes protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18237
      Conserved Domains (2) summary
      cd03277
      Location:947 → 1052
      ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
      cl25732
      Location:22 → 1049
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18237.2

    Gene LinkOut

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