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    atg-2 Autophagy-related protein 2 [ Caenorhabditis elegans ]

    Gene ID: 180949, updated on 4-Jan-2025

    Summary

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    Official Symbol
    atg-2
    Official Full Name
    Autophagy-related protein 2
    Primary source
    WormBase:WBGene00019748
    Locus tag
    CELE_M03A8.2
    See related
    AllianceGenome:WB:WBGene00019748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Involved in positive regulation of autophagy. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore and phagophore assembly site. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and spermathecal-uterine junction. Orthologous to several human genes including ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See atg-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (6809095..6817214)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene TLDc domain-containing protein Neighboring gene ncRNA Neighboring gene SCP2 domain-containing protein Neighboring gene GEX Interacting protein Neighboring gene ZM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegans. Sohn J, et al. Autophagy, 2024 Jul 20. PMID 38963038
    2. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Lu Q, et al. Dev Cell, 2011 Aug 16. PMID 21802374
    3. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
    4. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article
    5. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related protein 2
    NP_509145.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6809095..6817214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076744.10 → NP_509145.3  Autophagy-related protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509145.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21480
      Conserved Domains (4) summary
      COG5043
      Location:14 → 185
      MRS6; Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
      pfam09333
      Location:2194 → 2279
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:15 → 97
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16909
      Location:2014 → 2171
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21480.3

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