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    spe-38 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 190181, updated on 2-Nov-2024

    Summary

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    Official Symbol
    spe-38
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00013121
    Locus tag
    CELE_Y52B11A.1
    See related
    AllianceGenome:WB:WBGene00013121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in sperm entry. Located in cell cortex. Is expressed in sperm and spermatid. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See spe-38 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (10964472..10966382, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Protein IMPACT homolog Neighboring gene cytochrome-b5 reductase Neighboring gene GTP-binding protein GEM Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans. Singaravelu G, et al. Dev Biol, 2012 May 15. PMID 22425620, Free PMC Article
    2. A role for sperm in regulation of egg-laying in the nematode C. elegans. McGovern M, et al. BMC Dev Biol, 2007 May 1. PMID 17472754, Free PMC Article
    3. The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization. Chatterjee I, et al. Development, 2005 Jun. PMID 15930110
    4. CRISPR/Cas9 Mediated Fluorescent Tagging of Caenorhabditis elegans SPE-38 Reveals a Complete Localization Pattern in Live Spermatozoa. Zuo Y, et al. Biomolecules, 2023 Mar 30. PMID 37189371, Free PMC Article
    5. Spatial Transcriptomics of Nematodes Identifies Sperm Cells as a Source of Genomic Novelty and Rapid Evolution. Rödelsperger C, et al. Mol Biol Evol, 2021 Jan 4. PMID 32785688, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel genetic and physical interaction between two critical sperm function molecules, SPE-38 and TRP-3/SPE-41 in C. elegans was unraveled.
      Title: The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans.
    2. SPE-38 was found to concentrate on the pseudopod of mature sperm
      Title: The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_492853.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10964472..10966382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060452.9 → NP_492853.2  Uncharacterized protein CELE_Y52B11A.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492853.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWF5
    Nucleotide Protein
    Heading Accession and Version

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