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    nhr-137 NR LBD domain-containing protein;Nuclear receptor [ Caenorhabditis elegans ]

    Gene ID: 183865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-137
    Official Full Name
    NR LBD domain-containing protein;Nuclear receptor
    Primary source
    WormBase:WBGene00003727
    Locus tag
    CELE_C56E10.4
    See related
    AllianceGenome:WB:WBGene00003727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-137 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (6661772..6669011, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein 96 Neighboring gene Nuclear receptor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein;Nuclear receptor
    NP_001024505.1
    • Confirmed by transcript evidence
    NP_001024506.1
    • Confirmed by transcript evidence
    NP_001041235.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6661772..6669011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029334.4 → NP_001024505.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEX1
      Conserved Domains (2) summary
      smart00430
      Location:168 → 329
      HOLI; Ligand binding domain of hormone receptors
      cl02596
      Location:52 → 73
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. NM_001029335.7 → NP_001024506.1  Nuclear receptor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3WFU1
      Conserved Domains (2) summary
      cd06916
      Location:67 → 142
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      smart00430
      Location:237 → 398
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001047770.5 → NP_001041235.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3WFU2
      Conserved Domains (1) summary
      smart00430
      Location:101 → 262
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version

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