itsn-1 Intersectin-1;SH3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: itsn-1
Official Full Name: Intersectin-1;SH3 domain-containing protein
Primary source: WormBase:WBGene00006405
Locus tag: CELE_Y116A8C.36
See related: AllianceGenome:WB:WBGene00006405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable molecular adaptor activity. Involved in positive regulation of synaptic vesicle endocytosis. Located in endocytic vesicle and presynaptic periactive zone. Is expressed in neurons; somatic nervous system; tail; and vulva. Orthologous to several human genes including ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See itsn-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (17119682..17126269)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that ITSN-1 and Eps15 proteins function in the same genetic pathway, and appear to function synergistically with the clathrin-coat-associated sorting protein, Dab-1, for viability.
Title: ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.
identifies dynamin, or a dynamin-controlled pathway, as a potential target for the negative regulatory role of ITSN-1
Title: Caenorhabditis elegans intersectin: a synaptic protein regulating neurotransmission.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y116A8C.36 (e-PCR)
- UniSTS:321853

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Intersectin-1;SH3 domain-containing protein

NP_001255927.1

Confirmed by transcript evidence

NP_001255928.1

Confirmed by transcript evidence

NP_001255929.1

Confirmed by transcript evidence

NP_001299978.1

Confirmed by transcript evidence

NP_001299979.1

Partially confirmed by transcript evidence

NP_001299980.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17119682..17126269

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313049.4 → NP_001299978.1 Intersectin-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AS36

Conserved Domains (9) summary

smart00027
Location:4 → 93

EH; Eps15 homology domain

cd11836
Location:667 → 721

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:786 → 838

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:965 → 1021

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:1028 → 1085

SH3; Src homology 3 domains

cd00052
Location:180 → 246

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam09798
Location:390 → 429

LCD1; DNA damage checkpoint protein

pfam14988
Location:387 → 578

DUF4515; Domain of unknown function (DUF4515)

cl21478
Location:423 → 544

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001268998.4 → NP_001255927.1 Intersectin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255927.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2T9

Conserved Domains (9) summary

smart00027
Location:4 → 93

EH; Eps15 homology domain

cd11836
Location:665 → 719

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:784 → 836

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:963 → 1019

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:1026 → 1083

SH3; Src homology 3 domains

cd00052
Location:180 → 246

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam09798
Location:390 → 429

LCD1; DNA damage checkpoint protein

pfam14988
Location:387 → 576

DUF4515; Domain of unknown function (DUF4515)

cl21478
Location:459 → 564

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001313050.3 → NP_001299979.1 SH3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUH0

Conserved Domains (6) summary

cd11836
Location:407 → 461

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:526 → 578

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:705 → 761

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:768 → 825

SH3; Src homology 3 domains

pfam09798
Location:130 → 169

LCD1; DNA damage checkpoint protein

cl21478
Location:163 → 284

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001268999.3 → NP_001255928.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255928.1

Status: REVIEWED

UniProtKB/TrEMBL

E6N0W0

Conserved Domains (6) summary

cd11836
Location:405 → 459

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:524 → 576

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:703 → 759

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:766 → 823

SH3; Src homology 3 domains

pfam09798
Location:130 → 169

LCD1; DNA damage checkpoint protein

cl21478
Location:199 → 304

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001313051.3 → NP_001299980.1 SH3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARL5

Conserved Domains (4) summary

cd11836
Location:214 → 268

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:333 → 385

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:512 → 568

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:575 → 632

SH3; Src homology 3 domains
NM_001269000.3 → NP_001255929.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255929.1

Status: REVIEWED

UniProtKB/TrEMBL

E6N0W1

Conserved Domains (5) summary

cd11836
Location:212 → 266

SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin

cd11837
Location:331 → 383

SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin

cd11839
Location:510 → 566

SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin

smart00326
Location:573 → 630

SH3; Src homology 3 domains

cl21478
Location:6 → 111

ATP-synt_B; ATP synthase B/B' CF(0)