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    Y110A7A.9 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y110A7A.9
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00022459
    Locus tag
    CELE_Y110A7A.9
    See related
    AllianceGenome:WB:WBGene00022459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in cytoplasm. Is expressed in head; intestine; pharynx; and rectal gland cell. Used to study high grade glioma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder and hypogonadotropic hypogonadism 14 with or without anosmia. Orthologous to human WDR11 (WD repeat domain 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y110A7A.9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (5119216..5123985)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Elongator complex protein 1 Neighboring gene Cell division cycle protein 27 homolog Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp31 Neighboring gene Fungal lipase-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_001021718.1
    • Confirmed by transcript evidence
    NP_001379750.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5119216..5123985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392266.1 → NP_001379750.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AW19
      Conserved Domains (2) summary
      COG2319
      Location:303 → 557
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:387 → 423
      7WD40; WD40 repeat [structural motif]

    2. NM_001026547.4 → NP_001021718.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ40
      Conserved Domains (3) summary
      COG2319
      Location:414 → 668
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:16 → 49
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:16 → 145
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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