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    toc-1 similar to Transporter Of divalent Cations [ Caenorhabditis elegans ]

    Gene ID: 175728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    toc-1
    Official Full Name
    similar to Transporter Of divalent Cations
    Primary source
    WormBase:WBGene00006590
    Locus tag
    CELE_ZC395.3
    See related
    AllianceGenome:WB:WBGene00006590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in zinc ion transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in nervous system. Orthologous to human SLC30A6 (solute carrier family 30 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See toc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5275289..5277791)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Co-chaperone protein daf-41 Neighboring gene 5-demethoxyubiquinone hydroxylase, mitochondrial Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. Fujimoto S, et al. Biochem J, 2016 Sep 1. PMID 27303047, Free PMC Article
    2. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article
    3. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Ewbank JJ, et al. Science, 1997 Feb 14. PMID 9020081
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    similar to Transporter Of divalent Cations
    NP_001367624.1
    • Product from WormBase gene class toc;
      Confirmed by transcript evidence
    NP_001379769.1
    • Product from WormBase gene class toc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5275289..5277791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379701.1 → NP_001367624.1  similar to Transporter Of divalent Cations [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EL5
      Conserved Domains (2) summary
      PRK13263
      Location:378 → 441
      ureE; urease accessory protein UreE; Provisional
      pfam01545
      Location:45 → 271
      Cation_efflux; Cation efflux family

    2. NM_001392094.1 → NP_001379769.1  similar to Transporter Of divalent Cations [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18272, Q23281
      Conserved Domains (2) summary
      PRK13263
      Location:360 → 423
      ureE; urease accessory protein UreE; Provisional
      pfam01545
      Location:27 → 253
      Cation_efflux; Cation efflux family
    Nucleotide Protein
    Heading Accession and Version

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