cdk-2 Cyclin-dependent kinase 2;Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdk-2
Official Full Name: Cyclin-dependent kinase 2;Protein kinase domain-containing protein
Primary source: WormBase:WBGene00019362
Locus tag: CELE_K03E5.3
See related: AllianceGenome:WB:WBGene00019362
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including pseudocleavage; regulation of mitotic cell cycle; and regulation of protein localization. Located in chromatin. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdk-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (3410013..3416368)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSgamma complex.
Title: Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex.
CYE-1/CDK-2 emerges as a critical regulator of stem cell maintenance. We suggest that cyclin E and Cdk-2 may be used broadly to control developmental regulators.
Title: Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans.
Rapid movement through the cell cycle is supported by constitutive CYE-1/CDK-2 activity; CYE-1 and CDK-2 promote the proliferative fate as RNAi depletion of cye-1 or cdk-2 in a glp-1 partial loss-of-function mutant causes premature meiotic entry.
Title: Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.
in wild-type animals, CKI-1/CKI in these cells maintained quiescence by inhibiting CYE-1/CDK-2, while sufficient CYE-1/CDK-2 remained to repress the terminal differentiation
Title: Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-9 (e-PCR)
- UniSTS:241762

K03E5.3 (e-PCR)
- UniSTS:322221

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-transcriptional regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pseudocleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclin-dependent kinase 2;Protein kinase domain-containing protein

NP_001021537.2

Confirmed by transcript evidence

NP_001337286.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3410013..3416368

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026366.4 → NP_001021537.2 Cyclin-dependent kinase 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O61847

Conserved Domains (1) summary

cd07829
Location:15 → 300

STKc_CDK_like; Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases
NM_001350362.4 → NP_001337286.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1T5HUJ2

Conserved Domains (1) summary

cl21453
Location:1 → 102

PKc_like; Protein Kinases, catalytic domain