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    C29F7.3 UMP-CMP kinase 1 [ Caenorhabditis elegans ]

    Gene ID: 181464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C29F7.3
    Official Full Name
    UMP-CMP kinase 1
    Primary source
    WormBase:WBGene00007812
    Locus tag
    CELE_C29F7.3
    See related
    AllianceGenome:WB:WBGene00007812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables UMP kinase activity. Involved in UDP biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C29F7.3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (13418840..13419934, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene CHK kinase-like domain-containing protein Neighboring gene Forkhead box protein fkh-3 Neighboring gene Forkhead box protein fkh-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. Kim S, et al. FEBS J, 2009 Sep. PMID 19645718
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (d)CMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UMP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP/dUMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dCMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UMP-CMP kinase 1
    NP_510236.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13418840..13419934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077835.5 → NP_510236.1  UMP-CMP kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17622
      Conserved Domains (2) summary
      cd01428
      Location:4 → 177
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01359
      Location:4 → 186
      UMP_CMP_kin_fam; UMP-CMP kinase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17622.1

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