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    C33G3.4 putative beta-mannosidase [ Caenorhabditis elegans ]

    Gene ID: 181517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C33G3.4
    Official Full Name
    putative beta-mannosidase
    Primary source
    WormBase:WBGene00007904
    Locus tag
    CELE_C33G3.4
    See related
    AllianceGenome:WB:WBGene00007904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C33G3.4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (14071162..14076298)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Dentin sialophosphoprotein-like Neighboring gene ncRNA Neighboring gene Non-specific serine/threonine protein kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative beta-mannosidase
    NP_510342.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14071162..14076298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077941.7 → NP_510342.1  putative beta-mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93324
      Conserved Domains (3) summary
      COG3250
      Location:28 → 713
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
      pfam00703
      Location:220 → 326
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:46 → 146
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93324.1

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