U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    F46H5.4 C2 DOCK-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180988, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    F46H5.4
    Official Full Name
    C2 DOCK-type domain-containing protein
    Primary source
    WormBase:WBGene00018520
    Locus tag
    CELE_F46H5.4
    See related
    AllianceGenome:WB:WBGene00018520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; developmental and epileptic encephalopathy 23; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to several human genes including DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See F46H5.4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    35
    Sequence:
    Chromosome: X; NC_003284.9 (7245064..7254610, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene putative arginine kinase F46H5.3 Neighboring gene ncRNA Neighboring gene AMPK1_CBM domain-containing protein Neighboring gene MATH domain-containing protein Neighboring gene Beta-lactamase-related domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    C2 DOCK-type domain-containing protein
    NP_509219.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7245064..7254610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076818.7 → NP_509219.1  C2 DOCK-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20487
      Conserved Domains (3) summary
      cd08696
      Location:589 → 765
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam06920
      Location:1488 → 1998
      DHR-2; Dock homology region 2
      pfam11878
      Location:88 → 167
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous