hcp-3 Histone H3-like centromeric protein hcp-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hcp-3
Official Full Name: Histone H3-like centromeric protein hcp-3
Primary source: WormBase:WBGene00001831
Locus tag: CELE_F58A4.3
See related: AllianceGenome:WB:WBGene00001831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in several processes, including negative regulation of mitotic centrosome separation; non-membrane-bounded organelle assembly; and protein localization to chromosome. Located in kinetochore and nucleus. Is expressed in embryonic cell; hyp3; hyp4; hyp7 syncytium; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hcp-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (9615306..9616470, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog.
Title: Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog.
Results suggest that acetylation of soluble H4 may stimulate the initial deposition of CENP-A(HCP-3)-H4 nucleosomes.
Title: Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-A(HCP-3) Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes.
RbAp46/48LIN-53 localizes to the centromere during metaphase in a CENP-A (HCP-3)- and M18BP1KNL-2-dependent manner, suggesting CENP-A loading may occur before anaphase.
Title: RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A4.3 (e-PCR)
- UniSTS:307723

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to chromosome	TAS Traceable Author Statement more info	PubMed
involved_in kinetochore assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromosome, centromeric region	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone H3-like centromeric protein hcp-3

NP_499128.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9615306..9616470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066727.7 → NP_499128.1 Histone H3-like centromeric protein hcp-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499128.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34470

Conserved Domains (2) summary

smart00428
Location:183 → 288

H3; Histone H3

pfam00125
Location:156 → 284

Histone; Core histone H2A/H2B/H3/H4