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    obr-4 Oxysterol-binding protein [ Caenorhabditis elegans ]

    Gene ID: 172253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obr-4
    Official Full Name
    Oxysterol-binding protein
    Primary source
    WormBase:WBGene00016331
    Locus tag
    CELE_C32F10.1
    See related
    AllianceGenome:WB:WBGene00016331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity. Predicted to be involved in lipid transport. Predicted to be active in Golgi apparatus; cytosol; and membrane. Is expressed in nervous system; reproductive system; and tail. Orthologous to human OSBPL9 (oxysterol binding protein like 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See obr-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (5829391..5834637)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-2 Neighboring gene alanine transaminase Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Homeobox domain-containing protein;Homeobox protein ceh-12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    2. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Oxysterol-binding protein
    NP_001367357.1
    • Confirmed by transcript evidence
    NP_491691.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5829391..5834637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059290.8 → NP_491691.1  Oxysterol-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01686
      Conserved Domains (3) summary
      cd13290
      Location:1 → 100
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam00169
      Location:1 → 93
      PH; PH domain
      pfam01237
      Location:318 → 666
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001380388.1 → NP_001367357.1  Oxysterol-binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7N6
      Conserved Domains (1) summary
      pfam01237
      Location:42 → 393
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version

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