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    cth-1 cystathionine gamma-lyase [ Caenorhabditis elegans ]

    Gene ID: 180079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cth-1
    Official Full Name
    cystathionine gamma-lyase
    Primary source
    WormBase:WBGene00009048
    Locus tag
    CELE_F22B8.6
    See related
    AllianceGenome:WB:WBGene00009048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cth-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (16100680..16102750)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MOSC domain-containing protein Neighboring gene G protein-coupled receptor;Seven TM Receptor Neighboring gene ncRNA Neighboring gene arginine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan and healthspan benefits of exogenous H(2)S in C. elegans are independent from effects downstream of eat-2 mutation. Ng LT, et al. NPJ Aging Mech Dis, 2020. PMID 32566245, Free PMC Article
    2. Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans. Mack HID, et al. BMC Genomics, 2022 Jan 4. PMID 34983389, Free PMC Article
    3. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article
    4. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    5. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-cysteine desulfhydrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-cystine L-cysteine-lyase (deaminating) IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-sulfur lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine gamma-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine gamma-lyase
    NP_001263906.1
    • Confirmed by transcript evidence
    NP_507053.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16100680..16102750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074652.6 → NP_507053.1  cystathionine gamma-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45391
      Conserved Domains (2) summary
      PRK09028
      Location:9 → 372
      PRK09028; cystathionine beta-lyase; Provisional
      pfam01053
      Location:8 → 372
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

    2. NM_001276977.3 → NP_001263906.1  cystathionine gamma-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ESE2
      Conserved Domains (1) summary
      pfam01053
      Location:2 → 341
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme
    Nucleotide Protein
    Heading Accession and Version

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