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    fer-1 C2 domain-containing protein;Sperm vesicle fusion protein fer-1 [ Caenorhabditis elegans ]

    Gene ID: 172659, updated on 9-Dec-2024

    Summary

    Official Symbol
    fer-1
    Official Full Name
    C2 domain-containing protein;Sperm vesicle fusion protein fer-1
    Primary source
    WormBase:WBGene00001414
    Locus tag
    CELE_F43G9.6
    See related
    AllianceGenome:WB:WBGene00001414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Involved in several processes, including amoeboid sperm motility; pseudopodium organization; and spermatogenesis. Located in neuronal cell body membrane; organelle membrane; and pseudopodium membrane. Is expressed in body wall muscle cell; spermatid; spermatocyte; and in male. Used to study limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9; hereditary angioedema; and muscular dystrophy (multiple). Orthologous to several human genes including DYSF (dysferlin) and MYOF (myoferlin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See fer-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (8623012..8631202, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cleavage and polyadenylation specificity factor subunit 5 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-tubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amoeboid sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pseudopodium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in pseudopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C2 domain-containing protein;Sperm vesicle fusion protein fer-1
    NP_001122477.1
    • Confirmed by transcript evidence
    NP_492337.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8623012..8631202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059936.4NP_492337.1  Sperm vesicle fusion protein fer-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17388
      Conserved Domains (9) summary
      smart00694
      Location:859897
      DysFC; Dysferlin domain, C-terminal region
      cd04017
      Location:9721105
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:13841507
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:17031832
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:734790
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:644718
      FerB; FerB (NUC096) domain
      pfam08165
      Location:548607
      FerA; FerA (NUC095) domain
      pfam16165
      Location:18922028
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:284374
      C2; C2 domain
    2. NM_001129005.4NP_001122477.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6N9
      Conserved Domains (9) summary
      smart00694
      Location:732770
      DysFC; Dysferlin domain, C-terminal region
      cd04017
      Location:845978
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:12571380
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:15761705
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:607663
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:517591
      FerB; FerB (NUC096) domain
      pfam08165
      Location:421480
      FerA; FerA (NUC095) domain
      pfam16165
      Location:17651903
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:157247
      C2; C2 domain