rib-2 Exostosin-2 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rib-2
Official Full Name: Exostosin-2 homolog
Primary source: WormBase:WBGene00004361
Locus tag: CELE_K01G5.6
See related: AllianceGenome:WB:WBGene00004361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity and heparan sulfate N-acetylglucosaminyltransferase activity. Contributes to glucuronosyltransferase activity. Involved in embryonic morphogenesis; heparan sulfate proteoglycan biosynthetic process; and pharynx development. Part of protein-containing complex. Used to study hereditary multiple exostoses. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rib-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (10742810..10746675)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that rib-2 is essential for embryonic development and heparan sulfate biosynthesis in C. elegans
Title: EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K01G5.7 (e-PCR)
- UniSTS:321548

K01G5.6 (e-PCR)
- UniSTS:311352

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables heparan sulfate N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Exostosin-2 homolog

NP_499368.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10742810..10746675

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066967.9 → NP_499368.1 Exostosin-2 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01705, O17920

Conserved Domains (3) summary

pfam03016
Location:175 → 399

Exostosin; Exostosin family

pfam06005
Location:85 → 138

DUF904; Protein of unknown function (DUF904)

pfam09258
Location:561 → 791

Glyco_transf_64; Glycosyl transferase family 64 domain