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    rhr-2 Ammonium transporter AmtB-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rhr-2
    Official Full Name
    Ammonium transporter AmtB-like domain-containing protein
    Primary source
    WormBase:WBGene00004359
    Locus tag
    CELE_B0240.1
    See related
    AllianceGenome:WB:WBGene00004359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ammonium channel activity. Predicted to be involved in ammonium homeostasis and ammonium transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including body wall musculature; head neurons; spermatheca; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; hemolytic anemia; and overhydrated hereditary stomatocytosis. Orthologous to human RHAG (Rh associated glycoprotein); RHBG (Rh family B glycoprotein); and RHCG (Rh family C glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rhr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (11727900..11730160, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Trehalase Neighboring gene ncRNA Neighboring gene Receptor-type guanylate cyclase daf-11;guanylate cyclase Neighboring gene Nucleoporin ndc-1 Neighboring gene Dendritic cell-specific transmembrane protein-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ammonia excretion in Caenorhabditis elegans: mechanism and evidence of ammonia transport of the Rhesus protein CeRhr-1. Adlimoghaddam A, et al. J Exp Biol, 2015 Mar. PMID 25740900, Free PMC Article
    2. Ammonia excretion in Caenorhabditis elegans: Physiological and molecular characterization of the rhr-2 knock-out mutant. Adlimoghaddam A, et al. Comp Biochem Physiol A Mol Integr Physiol, 2016 May. PMID 26872996
    3. CeRh1 (rhr-1) is a dominant Rhesus gene essential for embryonic development and hypodermal function in Caenorhabditis elegans. Ji Q, et al. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595629, Free PMC Article
    4. Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Sharabi K, et al. Proc Natl Acad Sci U S A, 2009 Mar 10. PMID 19237558, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ammonium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ammonium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ammonium homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ammonium transporter AmtB-like domain-containing protein
    NP_505961.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11727900..11730160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073560.7 → NP_505961.1  Ammonium transporter AmtB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17463, Q9N2M5
      Conserved Domains (1) summary
      pfam00909
      Location:21 → 426
      Ammonium_transp; Ammonium Transporter Family
    Nucleotide Protein
    Heading Accession and Version

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