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    CLEC18C C-type lectin domain family 18 member C [ Homo sapiens (human) ]

    Gene ID: 283971, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CLEC18Cprovided by HGNC
    Official Full Name
    C-type lectin domain family 18 member Cprovided by HGNC
    Primary source
    HGNC:HGNC:28538
    See related
    Ensembl:ENSG00000157335 MIM:616573; AllianceGenome:HGNC:28538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRCL; MRCL3
    Summary
    Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney (RPKM 27.4) and testis (RPKM 7.1) See more
    Orthologs
    all
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    Genomic context

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    See CLEC18C in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70173787..70186895)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75983920..75997950)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70207690..70220798)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70121188-70121409 Neighboring gene ribosomal protein S10 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70148769-70149711 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene uncharacterized LOC400541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70200631-70201130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70221261-70222190 Neighboring gene uncharacterized LOC105371328 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70238115-70238280 Neighboring gene small nucleolar RNA U13 Neighboring gene SMG1 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. Huang YL, et al. J Biol Chem, 2015 Aug 28. PMID 26170455, Free PMC Article
    2. The C-type lectin-like domain superfamily. Zelensky AN, et al. FEBS J, 2005 Dec. PMID 16336259
    3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34761

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables polysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 18 member C
    Names
    mannose receptor-like 3
    mannose receptor-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173619.4 → NP_775890.2  C-type lectin domain family 18 member C precursor

      See identical proteins and their annotated locations for NP_775890.2

      Status: VALIDATED

      Source sequence(s)
      AC009060
      Consensus CDS
      CCDS32473.1
      UniProtKB/Swiss-Prot
      Q8IUW8, Q8NCF0
      UniProtKB/TrEMBL
      F5H550
      Related
      ENSP00000444875.2, ENST00000541793.7
      Conserved Domains (2) summary
      cd00037
      Location:310 → 434
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:50 → 183
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      70173787..70186895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433992.1 → XP_047289948.1  C-type lectin domain family 18 member C isoform X2

      UniProtKB/TrEMBL
      Q7Z4U9

    2. XM_047433991.1 → XP_047289947.1  C-type lectin domain family 18 member C isoform X1

      UniProtKB/TrEMBL
      B4DPF2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      75983920..75997950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380143.1 → XP_054236118.1  C-type lectin domain family 18 member C isoform X3

      UniProtKB/TrEMBL
      F8W692

    2. XM_054380146.1 → XP_054236121.1  C-type lectin domain family 18 member C isoform X5

      UniProtKB/TrEMBL
      F8W692

    3. XM_054380147.1 → XP_054236122.1  C-type lectin domain family 18 member C isoform X6

      UniProtKB/TrEMBL
      Q7Z4U9

    4. XM_054380144.1 → XP_054236119.1  C-type lectin domain family 18 member C isoform X4

      UniProtKB/TrEMBL
      B4DPF2

    5. XM_054380145.1 → XP_054236120.1  C-type lectin domain family 18 member C isoform X5

      UniProtKB/TrEMBL
      F8W692
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCF0.2 GenPept UniProtKB/Swiss-Prot:Q8NCF0

    Gene LinkOut

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