gnl2 G protein nucleolar 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnl2provided by ZNC
Official Full Name: G protein nucleolar 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2317
See related: Ensembl:ENSDARG00000098080 AllianceGenome:ZFIN:ZDB-GENE-040426-2317
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65800; zgc:77319; wu:fc15c12
Summary: Predicted to enable GTP binding activity. Acts upstream of or within several processes, including cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including head; immature eye; midbrain; neural plate; and segmental plate. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (33902082..33925877)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (33948052..33971847)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.
Title: The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

fc15c12.x1 (e-PCR)
- UniSTS:203821

fc78h02.y1 (e-PCR)
- UniSTS:194531

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: nucleolar GTP-binding protein 2

Names: guanine nucleotide binding protein-like 2 (nucleolar)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213224.1 → NP_998389.1 nucleolar GTP-binding protein 2

See identical proteins and their annotated locations for NP_998389.1

Status: PROVISIONAL

Source sequence(s)

BC065960

UniProtKB/TrEMBL

Q7SZQ9

Related

ENSDARP00000140260.1, ENSDART00000161807.2

Conserved Domains (3) summary

cd01858
Location:209 → 365

NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases

COG1161
Location:198 → 475

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

pfam08153
Location:44 → 174

NGP1NT; NGP1NT (NUC091) domain