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    rps6ka3a ribosomal protein S6 kinase a, polypeptide 3a [ Danio rerio (zebrafish) ]

    Gene ID: 338219, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rps6ka3aprovided by ZNC
    Official Full Name
    ribosomal protein S6 kinase a, polypeptide 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-119
    See related
    Ensembl:ENSDARG00000035556 AllianceGenome:ZFIN:ZDB-GENE-030219-119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rps6ka3; zgc:56006; id:ibd1103; wu:fk86e02; si:ch211-114c12.12
    Summary
    Predicted to enable ribosomal protein S6 kinase activity. Acts upstream of or within digestive tract development and skin development. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including epidermis; lateral mesoderm; otic vesicle; periderm; and pronephric duct. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See rps6ka3a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24009668..24029230, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23505868..23525458, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 2a Neighboring gene eukaryotic translation initiation factor 1A X-linked a Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1a Neighboring gene CTD nuclear envelope phosphatase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine. Makky K, et al. Dev Biol, 2007 Mar 15. PMID 17222402, Free PMC Article
    2. Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. Ma J, et al. Elife, 2021 Jun 24. PMID 34165081, Free PMC Article
    3. Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Kahsay A, et al. Sci Rep, 2022 Oct 13. PMID 36229514, Free PMC Article
    4. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893
    5. Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Kohn M, et al. Trends Genet, 2006 Apr. PMID 16517001

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skin development IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-1
    Names
    ribosomal protein S6 kinase, polypeptide 3
    ribosomal protein S6 kinase, polypeptide 3a
    NP_997951.1
    XP_005165175.1
    XP_068077214.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212786.1 → NP_997951.1  ribosomal protein S6 kinase alpha-1

      See identical proteins and their annotated locations for NP_997951.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045856
      UniProtKB/TrEMBL
      Q7ZVH8
      Related
      ENSDARP00000051545.4, ENSDART00000051546.6
      Conserved Domains (4) summary
      smart00220
      Location:59 → 318
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:63 → 379
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:395 → 732
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:414 → 671
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      24009668..24029230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165118.5 → XP_005165175.1  ribosomal protein S6 kinase alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ID09, A0A8M2BCC5
      Conserved Domains (4) summary
      smart00220
      Location:59 → 318
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:63 → 379
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:395 → 733
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:415 → 672
      Pkinase; Protein kinase domain

    2. XM_068221113.1 → XP_068077214.1  ribosomal protein S6 kinase alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q888

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394575.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      16527..34891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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