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    Lipo1 lipase, member O1 [ Mus musculus (house mouse) ]

    Gene ID: 329055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipo1provided by MGI
    Official Full Name
    lipase, member O1provided by MGI
    Primary source
    MGI:MGI:3647308
    See related
    Ensembl:ENSMUSG00000079342 AllianceGenome:MGI:3647308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5097; EG329055
    Summary
    Predicted to enable sterol ester esterase activity. Predicted to be involved in sterol metabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Lipo1 in Genome Data Viewer
    Location:
    19 C1; 19 29.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33753437..33764852, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33776037..33787452, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8980 Neighboring gene STARR-seq mESC enhancer starr_45979 Neighboring gene STARR-seq mESC enhancer starr_45980 Neighboring gene lipase, member O2 Neighboring gene STARR-seq mESC enhancer starr_45981 Neighboring gene STARR-seq mESC enhancer starr_45982 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45983 Neighboring gene STARR-seq mESC enhancer starr_45985 Neighboring gene predicted gene, 23095

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Holmes RS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Sep. PMID 20598663, Free PMC Article
    2. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Ozyildirim AM, et al. Invest Ophthalmol Vis Sci, 2005 May. PMID 15851553
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipase, member O1
    Names
    lipase, member O3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323065.1 → NP_001309994.1  lipase, member O1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC098875, AC122846, CK616672, CK617048
      Consensus CDS
      CCDS89380.1
      UniProtKB/TrEMBL
      F6WYC8
      Related
      ENSMUSP00000118385.3, ENSMUST00000148137.9
      Conserved Domains (3) summary
      pfam00561
      Location:77 → 375
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:33 → 94
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:77 → 242
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      33753437..33764852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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