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    Dnajc24 DnaJ heat shock protein family (Hsp40) member C24 [ Mus musculus (house mouse) ]

    Gene ID: 99349, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dnajc24provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C24provided by MGI
    Primary source
    MGI:MGI:1919522
    See related
    Ensembl:ENSMUSG00000027166 AllianceGenome:MGI:1919522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dph4; Zcsl3; MmDjC7; 1700030A21Rik; 2610027M02Rik
    Summary
    Predicted to enable ATPase activator activity; ferrous iron binding activity; and zinc ion binding activity. Involved in protein histidyl modification to diphthamide. Is active in actin cytoskeleton. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.3), CNS E14 (RPKM 6.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc24 in Genome Data Viewer
    Location:
    2 E3; 2 55.46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (105797053..105833894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (105966708..106003549, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene paired box 6 Neighboring gene STARR-seq mESC enhancer starr_05317 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene Pax6 downstream regulatory region Neighboring gene RB enhancer downstream of Pax6 Neighboring gene STARR-seq mESC enhancer starr_05318 Neighboring gene STARR-seq mESC enhancer starr_05319 Neighboring gene STARR-positive B cell enhancer ABC_E639 Neighboring gene IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:105843384-105843567 Neighboring gene STARR-seq mESC enhancer starr_05320 Neighboring gene doublecortin domain containing 5 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05321 Neighboring gene STARR-seq mESC enhancer starr_05322 Neighboring gene predicted gene, 46755

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new soluble murine J-domain protein that stimulates BiP, Hsc70 and DnaK ATPase activity with different efficiencies. Kroczynska B, et al. Gene, 2001 Aug 8. PMID 11595173
    2. Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. Webb TR, et al. J Cell Sci, 2008 Oct 1. PMID 18765564, Free PMC Article
    3. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mouse that was mutant for the gene, Dph4, was identified.
      Title: Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 24
    Names
    CSL-type zinc finger-containing protein 3
    DPH4 homolog (JJJ3, S. cerevisiae)
    DnaJ (Hsp40) homolog, subfamily C, member 24
    diphthamide biosynthesis protein 4
    j domain protein DjC7
    zinc finger, CSL-type containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026992.3 → NP_081268.1  dnaJ homolog subfamily C member 24

      See identical proteins and their annotated locations for NP_081268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK006521, AV331303
      Consensus CDS
      CCDS16501.1
      UniProtKB/Swiss-Prot
      Q91ZF0, Q9D9S7
      Related
      ENSMUSP00000099615.5, ENSMUST00000102555.11
      Conserved Domains (2) summary
      pfam00226
      Location:10 → 78
      DnaJ; DnaJ domain
      pfam05207
      Location:94 → 147
      zf-CSL; CSL zinc finger

    RNA

    1. NR_033993.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK006521, AK011571, AV331303

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      105797053..105833894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZF0.4 GenPept UniProtKB/Swiss-Prot:Q91ZF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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