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    Ctps1 cytidine 5'-triphosphate synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 51797, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ctps1provided by MGI
    Official Full Name
    cytidine 5'-triphosphate synthase 1provided by MGI
    Primary source
    MGI:MGI:1858304
    See related
    Ensembl:ENSMUSG00000028633 AllianceGenome:MGI:1858304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctps
    Summary
    Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in lymphocyte proliferation and nucleobase-containing small molecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoophidium and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 19.6), bladder adult (RPKM 15.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctps1 in Genome Data Viewer
    Location:
    4 D2.1; 4 56.52 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120397065..120427473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120539868..120570276, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Scm polycomb group homolog 1 Neighboring gene STARR-seq mESC enhancer starr_11247 Neighboring gene STARR-seq mESC enhancer starr_11248 Neighboring gene STARR-seq mESC enhancer starr_11249 Neighboring gene schlafen like 1 Neighboring gene predicted gene 8439 Neighboring gene STARR-seq mESC enhancer starr_11251 Neighboring gene predicted gene, 29891

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair. Tang R, et al. Arterioscler Thromb Vasc Biol, 2013 Oct. PMID 24008161, Free PMC Article
    2. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. Balzarini J, et al. J Biol Chem, 2012 Aug 31. PMID 22730407, Free PMC Article
    3. Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Soudais C, et al. Nat Commun, 2024 Mar 4. PMID 38438357, Free PMC Article
    4. CTPS and IMPDH form cytoophidia in developmental thymocytes. Peng M, et al. Exp Cell Res, 2021 Aug 1. PMID 34022203
    5. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
      Title: CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair.
    2. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
      Title: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CTP synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CTP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoophidium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoophidium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTP synthase 1
    Names
    CTP synthetase 1
    UTP--ammonia ligase 1
    NP_001342420.1
    NP_058028.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355491.1 → NP_001342420.1  CTP synthase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK148259, AK161110, AL611924, CD363725
      Consensus CDS
      CCDS18591.1
      UniProtKB/Swiss-Prot
      P70698, Q922Y4
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 556
      PLN02327; CTP synthase

    2. NM_016748.2 → NP_058028.2  CTP synthase 1

      See identical proteins and their annotated locations for NP_058028.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK146476, AK148259, AK161110, CD363725
      Consensus CDS
      CCDS18591.1
      UniProtKB/Swiss-Prot
      P70698, Q922Y4
      Related
      ENSMUSP00000030381.8, ENSMUST00000030381.8
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 556
      PLN02327; CTP synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120397065..120427473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70698.2 GenPept UniProtKB/Swiss-Prot:P70698

    Gene LinkOut

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