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    Zfp275 zinc finger protein 275 [ Mus musculus (house mouse) ]

    Gene ID: 27081, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp275provided by MGI
    Official Full Name
    zinc finger protein 275provided by MGI
    Primary source
    MGI:MGI:1350985
    See related
    Ensembl:ENSMUSG00000031365 AllianceGenome:MGI:1350985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DXPas8; DXBay20; DXHXS52; 5430431L06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human ZNF275 (zinc finger protein 275). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.4), ovary adult (RPKM 6.4) and 28 other tissues See more
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    Genomic context

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    See Zfp275 in Genome Data Viewer
    Location:
    X A7.3; X 37.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72386190..72402686)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73342593..73359080)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32150 Neighboring gene paraneoplastic antigen MA3 pseudogene Neighboring gene PNMA family member 6E Neighboring gene zinc finger protein 92

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Encyclopedia of the mouse genome III. October 1993. Mouse X chromosome. Brown SD, et al. Mamm Genome, 1993. PMID 8268681
    2. Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome. Heilig R, et al. Nature, 1987 Jul 9-15. PMID 3600794
    3. Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Avner P, et al. Proc Natl Acad Sci U S A, 1987 Mar. PMID 2882509, Free PMC Article
    4. Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28. Faust CJ, et al. Genomics, 1991 Sep. PMID 1684949
    5. Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R). Faust CJ, et al. Genomics, 1993 Feb. PMID 8449515

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 275

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160229.1 → NP_001153701.1  zinc finger protein 275 isoform 2

      See identical proteins and their annotated locations for NP_001153701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK142957, AL732461
      Consensus CDS
      CCDS53097.1
      UniProtKB/TrEMBL
      Q3UQ14
      Related
      ENSMUSP00000110143.2, ENSMUST00000114499.8
      Conserved Domains (4) summary
      COG5048
      Location:128 → 343
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:49 → 69
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 280
      zf-H2C2_2; Zinc-finger double domain

    2. NM_031494.2 → NP_113682.2  zinc finger protein 275 isoform 1

      See identical proteins and their annotated locations for NP_113682.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732461, BC138003, BY010614, CF535607, CJ130997
      Consensus CDS
      CCDS30199.2
      UniProtKB/TrEMBL
      G3X904
      Related
      ENSMUSP00000033731.4, ENSMUST00000033731.4
      Conserved Domains (5) summary
      COG5048
      Location:250 → 465
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:365 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:377 → 402
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72386190..72402686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528055.5 → XP_006528118.1  zinc finger protein 275 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:83 → 336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 233
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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