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    MSW1 tryptophan--tRNA ligase MSW1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSW1
    Official Full Name
    tryptophan--tRNA ligase MSW1
    Primary source
    SGD:S000002676
    Locus tag
    YDR268W
    See related
    AllianceGenome:SGD:S000002676; FungiDB:YDR268W; VEuPathDB:YDR268W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tryptophan-tRNA ligase activity. Involved in mitochondrial tryptophanyl-tRNA aminoacylation. Located in mitochondrion. Used to study mitochondrial metabolism disease. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSW1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1004004..1005143)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HEL2 Neighboring gene iron-sulfur cluster assembly protein CIA1 Neighboring gene Cu(2+)-transporting P-type ATPase CCC2 Neighboring gene hydroxyacylglutathione hydrolase GLO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An yeast nuclear mutation conferring temperature-sensitivity to the mitochondrial tryptophanyl-tRNA synthetase. Entrup R, et al. Curr Genet, 1992 Apr. PMID 1525855
    2. MSW, a yeast gene coding for mitochondrial tryptophanyl-tRNA synthetase. Myers AM, et al. J Biol Chem, 1985 Dec 5. PMID 2999114
    3. Investigation in yeast of novel variants in mitochondrial aminoacyl-tRNA synthetases WARS2, NARS2, and RARS2 genes associated with mitochondrial diseases. Figuccia S, et al. Hum Mol Genet, 2024 Sep 3. PMID 39230874
    4. Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae. Myers AM, et al. EMBO J, 1985 Aug. PMID 3905388, Free PMC Article
    5. Mutations in the mitochondrial tryptophanyl-tRNA synthetase cause growth retardation and progressive leukoencephalopathy. Maffezzini C, et al. Mol Genet Genomic Med, 2019 Jun. PMID 30920170, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigation in yeast of novel variants in mitochondrial aminoacyl-tRNA synthetases WARS2, NARS2, and RARS2 genes associated with mitochondrial diseases.
      Title: Investigation in yeast of novel variants in mitochondrial aminoacyl-tRNA synthetases WARS2, NARS2, and RARS2 genes associated with mitochondrial diseases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tryptophan-tRNA ligase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase MSW1
    NP_010554.1
    • Mitochondrial tryptophanyl-tRNA synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1004004..1005143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180576.1 → NP_010554.1  TPA: tryptophan--tRNA ligase MSW1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ2, P04803
      UniProtKB/TrEMBL
      A6ZYM1, B3LG22, B5VGF2, C7GS89, C8Z5I1, G2WB11, N1PAG7
      Conserved Domains (1) summary
      TIGR00233
      Location:33 → 379
      trpS; tryptophanyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04803.2

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