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    SEC9 Sec9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC9
    Official Full Name
    Sec9p
    Primary source
    SGD:S000003241
    Locus tag
    YGR009C
    See related
    AllianceGenome:SGD:S000003241; FungiDB:YGR009C; VEuPathDB:YGR009C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSS7
    Summary
    Enables SNAP receptor activity. Involved in exocytosis and vesicle fusion. Located in cellular bud neck and cytosol. Part of SNARE complex. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP23 (synaptosome associated protein 23) and SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC9 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (509047..511002, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ethanolamine-phosphate cytidylyltransferase Neighboring gene ATPase-stabilizing factor family protein Neighboring gene nicotinamide-nucleotide adenylyltransferase NMA2 Neighboring gene putative cysteine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Hattendorf DA, et al. Nature, 2007 Mar 29. PMID 17392788
    2. An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain. Van Komen JS, et al. J Cell Biol, 2006 Jan 16. PMID 16401725, Free PMC Article
    3. The polybasic juxtamembrane region of Sso1p is required for SNARE function in vivo. Van Komen JS, et al. Eukaryot Cell, 2005 Dec. PMID 16339720, Free PMC Article
    4. Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Sivaram MV, et al. Biochemistry, 2005 Apr 26. PMID 15835919
    5. Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion. Lai Y, et al. Phys Biol, 2015 Apr 21. PMID 25898400, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sec9p
    NP_011523.3
    • t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      509047..511002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181138.3 → NP_011523.3  TPA: Sec9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011523.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUE6, P40357
      UniProtKB/TrEMBL
      A6ZV01, B3LIK7, C7GK79, C8Z8Q3, N1P3E5
      Conserved Domains (2) summary
      cd15857
      Location:596 → 649
      SNARE_SEC9C; C-terminal SNARE motif of SEC9
      cd15886
      Location:431 → 500
      SNARE_SEC9N; N-terminal SNARE motif of SEC9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40357.1

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