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    CRP1 Crp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRP1
    Official Full Name
    Crp1p
    Primary source
    SGD:S000001189
    Locus tag
    YHR146W
    See related
    AllianceGenome:SGD:S000001189; FungiDB:YHR146W; VEuPathDB:YHR146W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity. Predicted to be involved in signal transduction. Is active in cell periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CRP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (390300..391697)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene deoxycytidine monophosphate deaminase Neighboring gene tRNA-Pro Neighboring gene mitochondrial 54S ribosomal protein YmL16 Neighboring gene snoRNA-binding rRNA-processing protein IMP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crp1p, a new cruciform DNA-binding protein in the yeast Saccharomyces cerevisiae. Rass U, et al. J Mol Biol, 2002 Nov 1. PMID 12419258
    2. Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast. Isoda T, et al. iScience, 2024 Jun 21. PMID 38832010, Free PMC Article
    3. The cruciform DNA-binding protein Crp1 stimulates the endonuclease activity of Mus81-Mms4 in Saccharomyces cerevisiae. Phung HTT, et al. FEBS Lett, 2020 Dec. PMID 32936932
    4. An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth. Smolka MB, et al. J Cell Biol, 2006 Dec 4. PMID 17130285, Free PMC Article
    5. α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast. Popova B, et al. Cells, 2021 Aug 28. PMID 34571878, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cruciform DNA-binding protein Crp1 stimulates the endonuclease activity of Mus81-Mms4 in Saccharomyces cerevisiae.
      Title: The cruciform DNA-binding protein Crp1 stimulates the endonuclease activity of Mus81-Mms4 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Crp1p
    NP_012016.1
    • Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      390300..391697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179277.1 → NP_012016.1  TPA: Crp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT54, B3LSR0, D3DL95, P38845
      UniProtKB/TrEMBL
      G2WFL9, N1P176
      Conserved Domains (2) summary
      cd02859
      Location:8 → 90
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      NF033645
      Location:215 → 385
      pilus_FilE; putative pilus assembly protein FilE
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38845.1

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