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    Klhdc4 kelch domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 234825, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhdc4provided by MGI
    Official Full Name
    kelch domain containing 4provided by MGI
    Primary source
    MGI:MGI:2384569
    See related
    Ensembl:ENSMUSG00000040263 AllianceGenome:MGI:2384569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G430025P05Rik
    Summary
    Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cerebral cortex ventricular layer. Orthologous to human KLHDC4 (kelch domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.5), CNS E14 (RPKM 9.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Klhdc4 in Genome Data Viewer
    Location:
    8 E1; 8 70.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122523047..122556322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121796308..121829583, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46065 Neighboring gene junctophilin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124353433-124353616 Neighboring gene STARR-positive B cell enhancer ABC_E1774 Neighboring gene predicted gene, 24283 Neighboring gene STARR-seq mESC enhancer starr_22928 Neighboring gene predicted gene, 26812 Neighboring gene STARR-seq mESC enhancer starr_22929

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Clone Names

    • MGC19372

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    kelch domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145605.2NP_663580.2  kelch domain-containing protein 4

      See identical proteins and their annotated locations for NP_663580.2

      Status: VALIDATED

      Source sequence(s)
      AC121975, AK161674, AV374981, BY086869
      Consensus CDS
      CCDS22729.1
      UniProtKB/Swiss-Prot
      Q8CIK0, Q921I2
      UniProtKB/TrEMBL
      G3X961
      Related
      ENSMUSP00000043439.11, ENSMUST00000045884.17
      Conserved Domains (4) summary
      sd00038
      Location:64115
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:431480
      Kelch_1; Kelch motif
      pfam13415
      Location:75127
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:174216
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122523047..122556322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248370.3XP_011246672.1  kelch domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8CIK0, Q921I2
      Conserved Domains (3) summary
      PLN02193
      Location:77314
      PLN02193; nitrile-specifier protein
      sd00038
      Location:64115
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:431480
      Kelch_1; Kelch motif
    2. XM_006530947.4XP_006531010.1  kelch domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      G3UZ63
      Conserved Domains (3) summary
      PLN02193
      Location:135270
      PLN02193; nitrile-specifier protein
      sd00038
      Location:133180
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:387436
      Kelch_1; Kelch motif
    3. XM_006530948.5XP_006531011.1  kelch domain-containing protein 4 isoform X3

      See identical proteins and their annotated locations for XP_006531011.1

      UniProtKB/TrEMBL
      G3UZG5
      Related
      ENSMUSP00000134487.2, ENSMUST00000174192.2
      Conserved Domains (3) summary
      PLN02193
      Location:15222
      PLN02193; nitrile-specifier protein
      sd00038
      Location:2782
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:339388
      Kelch_1; Kelch motif
    4. XM_006530950.5XP_006531013.1  kelch domain-containing protein 4 isoform X4

      Conserved Domains (3) summary
      PLN02193
      Location:47182
      PLN02193; nitrile-specifier protein
      sd00038
      Location:4592
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:299348
      Kelch_1; Kelch motif
    5. XM_030243519.2XP_030099379.1  kelch domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      G3UZG5
      Conserved Domains (3) summary
      PLN02193
      Location:15222
      PLN02193; nitrile-specifier protein
      sd00038
      Location:2782
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:339388
      Kelch_1; Kelch motif
    6. XM_017312755.3XP_017168244.1  kelch domain-containing protein 4 isoform X5

      Conserved Domains (3) summary
      PLN02193
      Location:39174
      PLN02193; nitrile-specifier protein
      sd00038
      Location:3784
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:291340
      Kelch_1; Kelch motif
    7. XM_006530952.5XP_006531015.1  kelch domain-containing protein 4 isoform X6

      Conserved Domains (3) summary
      PLN02193
      Location:479
      PLN02193; nitrile-specifier protein
      sd00038
      Location:254
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:196245
      Kelch_1; Kelch motif