MDM38 ribosome-binding protein MDM38 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MDM38
Official Full Name: ribosome-binding protein MDM38
Primary source: SGD:S000005387
Locus tag: YOL027C
See related: AllianceGenome:SGD:S000005387; FungiDB:YOL027C; VEuPathDB:YOL027C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MKH1
Summary: Enables mitochondrial ribosome binding activity. Involved in several processes, including intracellular potassium ion homeostasis; monoatomic cation transport; and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. Used to study Wolf-Hirschhorn syndrome and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Dissecting structure and function of the monovalent cation/H[+] antiporters Mdm38 and Ylh47 in Saccharomyces cerevisiae.
Title: Dissecting structure and function of the monovalent cation/H(+) antiporters Mdm38 and Ylh47 in Saccharomyces cerevisiae.
The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain.
Title: The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain.
Identified the conserved ribosome-binding domain of Mdm38 and determine the crystal structure at 2.1 A resolution.
Title: Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.
The role that mdm38 plays in mitochondrial export machinery is discussed.
Title: Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mitochondrial ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial translation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014615.1

Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome

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