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    MKK2 putative mitogen-activated protein kinase kinase MKK2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MKK2
    Official Full Name
    putative mitogen-activated protein kinase kinase MKK2
    Primary source
    SGD:S000006061
    Locus tag
    YPL140C
    See related
    AllianceGenome:SGD:S000006061; FungiDB:YPL140C; VEuPathDB:YPL140C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPI6; SSP33
    Summary
    Predicted to enable MAP kinase kinase activity. Involved in cell integrity MAPK cascade; pexophagy; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MKK2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (287514..289034, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L33A Neighboring gene protein kinase FRK1 Neighboring gene Ume1p Neighboring gene Spp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Rancati G, et al. Cell, 2008 Nov 28. PMID 19041751, Free PMC Article
    2. Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway. Jiménez-Sánchez M, et al. J Biol Chem, 2007 Oct 26. PMID 17711850
    3. Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2. González-Rubio G, et al. Int J Mol Sci, 2021 Jan 23. PMID 33498635, Free PMC Article
    4. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans. Navarro-García F, et al. Microbiology (Reading), 1998 Feb. PMID 9493378
    5. Coordination of the mating and cell integrity mitogen-activated protein kinase pathways in Saccharomyces cerevisiae. Buehrer BM, et al. Mol Cell Biol, 1997 Nov. PMID 9343415, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that that two alternative MAPKKs, Pbs2 and Mkk2, can be forced to functionally replace the mating MAPKK Ste7, but only if the proper set of recruitment interactions are grafted onto their catalytic domains.
      Title: Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.
    2. Retrophosphorylation of MKK2 by the SLT2 MAPK in the yeast cell integrity pathway is reported.
      Title: Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell integrity MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell integrity MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative mitogen-activated protein kinase kinase MKK2
    NP_015185.1
    • MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      287514..289034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183954.1 → NP_015185.1  TPA: putative mitogen-activated protein kinase kinase MKK2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3M8, P32491
      UniProtKB/TrEMBL
      A6ZWB3, B3LKT6, B5VT26, C7GJ92, C8ZIN9, G2WP42, N1NX19
      Conserved Domains (1) summary
      cd06621
      Location:212 → 499
      PKc_Pek1_like; Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32491.2

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