Srpx2 sushi-repeat-containing protein, X-linked 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srpx2provided by MGI
Official Full Name: sushi-repeat-containing protein, X-linked 2provided by MGI
Primary source: MGI:MGI:1916042
See related: Ensembl:ENSMUSG00000031253 AllianceGenome:MGI:1916042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SRP; SRPUL; 1110039C07Rik
Summary: Enables signaling receptor binding activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and vocalization behavior. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; limb; musculoskeletal system; peritoneum; and testis. Orthologous to human SRPX2 (sushi repeat containing protein X-linked 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 8.1), mammary gland adult (RPKM 5.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: X E3; X 55.47 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (132809155..132833195)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (133908416..133932448)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex.
Title: C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex.
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
Title: The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
Unsupervised hierarchical clustering using SRPX2 expression did not identify genotype or injury-specific clusters. Data demonstrate that SRPX2 expression in the hypothalamus is resistant to genetic deficiencies in the urokinase-system or to the hypothalamus-affecting TBI.
Title: Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
we show that mice lacking SRPX2 show a specific reduction in excitatory VGlut2 synapses in the cerebral cortex, while VGlut1 and inhibitory synapses were largely unaffected. SRPX2 KO mice also exhibit an abnormal ultrasonic vocalization ontogenetic profile in neonatal pups, and reduced preference for social novelty.
Title: Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables hepatocyte growth factor binding	ISO Inferred from Sequence Orthology more info
enables hepatocyte growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sushi repeat-containing protein SRPX2

Names: sushi-repeat containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083895.3 → NP_001077364.2 sushi repeat-containing protein SRPX2 precursor

See identical proteins and their annotated locations for NP_001077364.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.The encoded protein contains an in-frame start site 41 codons upstream of the currently annotated site, but Kozak sequence considerations and the presence of a signal peptide in the shorter version make the shorter version the more likely protein product.

Source sequence(s)

AK136935, AL691421, BB843885, BB848735

Consensus CDS

CCDS41119.2

UniProtKB/Swiss-Prot

B1AVI6, Q3UVU0, Q8K1F8, Q8K4W6, Q8R054

Related

ENSMUSP00000108929.3, ENSMUST00000113304.2

Conserved Domains (3) summary

cd00033
Location:267 → 322

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam02494
Location:180 → 262

HYR; HYR domain

pfam13778
Location:337 → 448

DUF4174; Domain of unknown function (DUF4174)
NM_026838.4 → NP_081114.2 sushi repeat-containing protein SRPX2 precursor

See identical proteins and their annotated locations for NP_081114.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The encoded protein contains an in-frame start site 41 codons upstream of the currently annotated site, but Kozak sequence considerations and the presence of a signal peptide in the shorter version make the shorter version the more likely protein product.

Source sequence(s)

AK136935, AL691421, BB843885, BB848735, BF470209, BQ560499, BQ830905, CN539245

Consensus CDS

CCDS41119.2

UniProtKB/Swiss-Prot

B1AVI6, Q3UVU0, Q8K1F8, Q8K4W6, Q8R054

Related

ENSMUSP00000033606.10, ENSMUST00000033606.15

Conserved Domains (3) summary

cd00033
Location:267 → 322

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam02494
Location:180 → 262

HYR; HYR domain

pfam13778
Location:337 → 448

DUF4174; Domain of unknown function (DUF4174)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

132809155..132833195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528606.3 → XP_006528669.1 sushi repeat-containing protein SRPX2 isoform X1

Conserved Domains (3) summary

cd00033
Location:244 → 299

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam02494
Location:157 → 239

HYR; HYR domain

pfam13778
Location:314 → 433

DUF4174; Domain of unknown function (DUF4174)