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    Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [ Mus musculus (house mouse) ]

    Gene ID: 19247, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ptpn11provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 11provided by MGI
    Primary source
    MGI:MGI:99511
    See related
    Ensembl:ENSMUSG00000043733 AllianceGenome:MGI:99511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; 2700084A17Rik
    Summary
    Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 24.0), genital fat pad adult (RPKM 23.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptpn11 in Genome Data Viewer
    Location:
    5 61.72 cM; 5 F
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121268596..121329460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121130533..121191397, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1 pseudogene Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene predicted gene, 32185 Neighboring gene rabphilin 3A Neighboring gene STARR-positive B cell enhancer ABC_E3611 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene ribosomal protein L6 Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (19)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables D1 dopamine receptor binding  
    enables cadherin binding  
    enables cadherin binding  
    enables cell adhesion molecule binding  
    enables cell adhesion molecule binding PubMed 
    enables cell adhesion molecule binding  
    enables histone H2AXY142 phosphatase activity  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables insulin receptor substrate binding  
    enables molecular adaptor activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables peptide hormone receptor binding PubMed 
    enables phospholipase binding  
    enables phosphoprotein phosphatase activity PubMed 
    enables phosphoprotein phosphatase activity  
    enables phosphotyrosine residue binding  
    enables phosphotyrosine residue binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein kinase binding PubMed 
    enables protein tyrosine kinase binding  
    enables protein tyrosine phosphatase activity PubMed 
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity, metal-dependent  
    enables receptor tyrosine kinase binding  
    enables receptor tyrosine kinase binding PubMed 
    enables receptor tyrosine kinase binding  
    enables signaling receptor complex adaptor activity  
    enables signaling receptor complex adaptor activity  
    Items 1 - 25 of 34
    Items 1 - 25 of 81
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation PubMed 
    acts_upstream_of_or_within Bergmann glial cell differentiation PubMed 
    acts_upstream_of_or_within DNA damage checkpoint signaling PubMed 
    involved_in ERBB signaling pathway  
    involved_in ERBB signaling pathway  
    involved_in atrioventricular canal development  
    involved_in atrioventricular canal development  
    acts_upstream_of_or_within axonogenesis PubMed 
    involved_in brain development  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within cerebellar cortex formation PubMed 
    acts_upstream_of_or_within cerebellar cortex formation PubMed 
    involved_in chromatin remodeling  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in face morphogenesis  
    involved_in face morphogenesis  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in genitalia development  
    involved_in genitalia development  
    acts_upstream_of_or_within glucose homeostasis PubMed 
    involved_in heart development  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue PubMed 
    acts_upstream_of_or_within hormone metabolic process PubMed 
    acts_upstream_of_or_within hormone-mediated signaling pathway PubMed 
    involved_in inner ear development  
    involved_in inner ear development  
    acts_upstream_of_or_within integrin-mediated signaling pathway PubMed 
    acts_upstream_of_or_within intestinal epithelial cell migration PubMed 
    acts_upstream_of_or_within lipid metabolic process PubMed 
    acts_upstream_of_or_within megakaryocyte development PubMed 
    acts_upstream_of_or_within microvillus organization PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within multicellular organismal reproductive process PubMed 
    acts_upstream_of_or_within negative regulation of cell adhesion mediated by integrin PubMed 
    involved_in negative regulation of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of cortisol secretion PubMed 
    acts_upstream_of_or_within negative regulation of growth hormone secretion PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion PubMed 
    acts_upstream_of_or_within negative regulation of insulin secretion PubMed 
    involved_in negative regulation of type I interferon production  
    involved_in negative regulation of type I interferon production  
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway PubMed 
    acts_upstream_of_or_within organ growth PubMed 
    involved_in peptidyl-tyrosine dephosphorylation  
    involved_in peptidyl-tyrosine dephosphorylation  
    acts_upstream_of_or_within platelet formation PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of focal adhesion assembly  
    acts_upstream_of_or_within positive regulation of hormone secretion PubMed 
    involved_in positive regulation of insulin receptor signaling pathway  
    involved_in positive regulation of insulin receptor signaling pathway  
    involved_in positive regulation of interferon-beta production PubMed 
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of mitotic cell cycle PubMed 
    involved_in positive regulation of ossification PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of signal transduction PubMed 
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in protein dephosphorylation  
    acts_upstream_of_or_within regulation of MAPK cascade PubMed 
    involved_in regulation of cell adhesion mediated by integrin  
    involved_in regulation of cell adhesion mediated by integrin  
    acts_upstream_of_or_within regulation of protein export from nucleus PubMed 
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of protein-containing complex assembly  
    acts_upstream_of signal transduction PubMed 
    acts_upstream_of_or_within triglyceride metabolic process PubMed 
    Items 1 - 25 of 81
    Component Evidence Code Pubs
    located_in cell junction PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol PubMed 
    located_in cytosol  
    located_in membrane PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane raft  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in stress fiber PubMed 

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 11
    Names
    SH2 domain-containing protein tyrosine phosphatase-2
    protein-tyrosine phosphatase SYP
    NP_001103462.1
    NP_035332.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109992.1NP_001103462.1  tyrosine-protein phosphatase non-receptor type 11 isoform b

      See identical proteins and their annotated locations for NP_001103462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK159501, BC057398, BM899214, CF751511
      Consensus CDS
      CCDS51637.1
      UniProtKB/Swiss-Prot
      P35235, Q3TQ84, Q64509, Q6PCL5
      Related
      ENSMUSP00000098333.3, ENSMUST00000100770.9
      Conserved Domains (3) summary
      cd09931
      Location:111218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
    2. NM_011202.3NP_035332.1  tyrosine-protein phosphatase non-receptor type 11 isoform a

      See identical proteins and their annotated locations for NP_035332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK159501, BC057398, BM899214, CF751511
      Consensus CDS
      CCDS39247.1
      UniProtKB/Swiss-Prot
      P35235
      Related
      ENSMUSP00000058757.8, ENSMUST00000054547.9
      Conserved Domains (3) summary
      cd09931
      Location:111218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121268596..121329460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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