CRD1 cardiolipin synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CRD1
Official Full Name: cardiolipin synthase
Primary source: SGD:S000002301
Locus tag: YDL142C
See related: AllianceGenome:SGD:S000002301; FungiDB:YDL142C; VEuPathDB:YDL142C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CLS1
Summary: Enables cardiolipin synthase (CMP-forming). Involved in several processes, including intracellular monoatomic ion homeostasis; mitochondrion organization; and protein targeting to membrane. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CRD1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (201719..202570, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crd1, which is located in the mitochondrial inner membrane, condenses phosphatidylglycerol together with CDP-diacylglycerol to obtain de novo synthesized Cardiolipin molecules.
Title: Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins.
Results demonstrate the existence of a novel mitochondria-vacuole signaling pathway mediated by cardiolipin synthesis.
Title: Cardiolipin mediates cross-talk between mitochondria and the vacuole.
mitochondrial biosynthesis of phosphatidylethanolamine is essential for the viability of yeast mutants lacking cardiolipin
Title: Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cardiolipin synthase (CMP-forming)	IBA Inferred from Biological aspect of Ancestor more info
enables cardiolipin synthase (CMP-forming)	IDA Inferred from Direct Assay more info	PubMed
enables cardiolipin synthase (CMP-forming)	IEA Inferred from Electronic Annotation more info
enables cardiolipin synthase (CMP-forming)	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphotransferase activity, for other substituted phosphate groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cardiolipin synthase

NP_010139.1

EC 2.7.8.41

Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

201719..202570 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180202.1 → NP_010139.1 TPA: cardiolipin synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010139.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRK6, P82260, Q07560

UniProtKB/TrEMBL

A6ZXI5, B3LH33, B5VFC7, C8Z6G0, G2WC19, N1P7M8

Conserved Domains (1) summary

COG0558
Location:66 → 231

PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]