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    Dnd1 DND microRNA-mediated repression inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 213236, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnd1provided by MGI
    Official Full Name
    DND microRNA-mediated repression inhibitor 1provided by MGI
    Primary source
    MGI:MGI:2447763
    See related
    Ensembl:ENSMUSG00000044595 AllianceGenome:MGI:2447763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ter; RBMS4
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within germ cell development. Located in cytoplasm. Is expressed in several structures, including allantois; central nervous system; gonad; head mesenchyme; and sensory organ. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 10.8), ovary adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnd1 in Genome Data Viewer
    Location:
    18 B2; 18 19.46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36896724..36899267, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36763671..36766214, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8710 Neighboring gene histidyl-tRNA synthetase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3227 Neighboring gene zinc finger, matrin type 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice. Bustamante-Marin XM, et al. Front Genet, 2023. PMID 37180974, Free PMC Article
    2. A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice. Noguchi T, et al. J Natl Cancer Inst, 1985 Aug. PMID 3860691
    3. Search for testicular cancer gene hits dead-end. Matin A, et al. Cell Cycle, 2005 Sep. PMID 16082220
    4. Spontaneous Testicular Teratomas in an Inbred Strain of Mice. Stevens LC, et al. Proc Natl Acad Sci U S A, 1954 Nov. PMID 16578442, Free PMC Article
    5. The role of dead-end in germ-cell tumor development. Zhu R, et al. Ann N Y Acad Sci, 2007 Dec. PMID 17905939, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.
      Title: Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.
    2. Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes.
      Title: Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes.
    3. The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.
      Title: The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.
    4. A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
      Title: A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
    5. A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cellsdagger.
      Title: A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
    6. Dnd1 loss caused defects in both spermatogenesis and oogenesis and results in testicular teratoma incidence.
      Title: Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.
    7. Results suggest multiple DND1 functions and link DND1 to initiation of epigenetic modifications in male germ cells.
      Title: The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
    8. Cultured Dead-end1 (Dnd1) mutant germ cells (CDGCs) were morphologically similar to embryonic stem cells (ESCs) and could be maintained in the naive pluripotent condition.
      Title: Derivation of pluripotent stem cells from nascent undifferentiated teratoma.
    9. DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase complex.
      Title: DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
    10. DND1 interacts with NANOS2 to load unique RNAs into the CCR4-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development
      Title: Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41452

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dead end protein homolog 1
    Names
    RNA-binding motif, single-stranded-interacting protein 4
    dead end homolog 1
    teratoma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173383.2 → NP_775559.2  dead end protein homolog 1

      See identical proteins and their annotated locations for NP_775559.2

      Status: VALIDATED

      Source sequence(s)
      AY321066, BC034897
      Consensus CDS
      CCDS29163.2
      UniProtKB/Swiss-Prot
      Q6VY05, Q8CFK7
      Related
      ENSMUSP00000054412.8, ENSMUST00000061522.8
      Conserved Domains (3) summary
      cd12487
      Location:57 → 134
      RRM1_DND1; RNA recognition motif 1 found in vertebrate dead end protein homolog 1 (DND1)
      pfam14709
      Location:253 → 333
      DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
      cl17169
      Location:136 → 218
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36896724..36899267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VY05.1 GenPept UniProtKB/Swiss-Prot:Q6VY05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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