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    Spink7 serine peptidase inhibitor, Kazal type 7 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 408198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spink7provided by MGI
    Official Full Name
    serine peptidase inhibitor, Kazal type 7 (putative)provided by MGI
    Primary source
    MGI:MGI:3644691
    See related
    Ensembl:ENSMUSG00000060201 AllianceGenome:MGI:3644691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ecg2; ECRG-2; EG408198
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Located in extracellular space. Orthologous to human SPINK7 (serine peptidase inhibitor Kazal type 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Spink7 in Genome Data Viewer
    Location:
    18 E1; 18 35.33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62725254..62729639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62592413..62596568, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neutrophils-derived Spink7 as one safeguard against experimental murine colitis. Zhao N, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Jun 1. PMID 33722746
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neutrophils-derived Spink7 as one safeguard against experimental murine colitis.
      Title: Neutrophils-derived Spink7 as one safeguard against experimental murine colitis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 7
    Names
    esophagus cancer-related gene 2 protein
    esophagus cancer-related gene-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001803.4 → NP_001001803.2  serine protease inhibitor Kazal-type 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124383
      Consensus CDS
      CCDS50304.1
      UniProtKB/Swiss-Prot
      F8WGH2, Q6IE32
      Related
      ENSMUSP00000075551.5, ENSMUST00000076194.6
      Conserved Domains (1) summary
      cl00097
      Location:41 → 85
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62725254..62729639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317940.2 → XP_017173429.1  serine protease inhibitor Kazal-type 7 isoform X1

      Conserved Domains (1) summary
      cl00097
      Location:62 → 92
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE32.2 GenPept UniProtKB/Swiss-Prot:Q6IE32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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