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    MBOAT4 membrane bound O-acyltransferase domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 619373, updated on 10-Dec-2024

    Summary

    Official Symbol
    MBOAT4provided by HGNC
    Official Full Name
    membrane bound O-acyltransferase domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:32311
    See related
    Ensembl:ENSG00000177669 MIM:611940; AllianceGenome:HGNC:32311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOAT; OACT4; FKSG89
    Summary
    Enables acyltransferase activity, transferring groups other than amino-acyl groups. Involved in peptidyl-serine octanoylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach (RPKM 1.5), gall bladder (RPKM 0.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MBOAT4 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30131671..30144665, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (30410588..30423543, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29989187..30002181, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene store-operated calcium entry associated regulatory factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19075 Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30013010-30013992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19076 Neighboring gene uncharacterized LOC124901927 Neighboring gene DCTN6 divergent transcript Neighboring gene dynactin subunit 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables O-acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide hormone processing TAS
    Traceable Author Statement
    more info
     
    involved_in peptidyl-serine octanoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ghrelin O-acyltransferase
    Names
    O-acyltransferase (membrane bound) domain containing 4
    O-acyltransferase domain-containing protein 4
    membrane-bound O-acyltransferase domain-containing protein 4
    NP_001094386.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100916.2NP_001094386.1  ghrelin O-acyltransferase

      See identical proteins and their annotated locations for NP_001094386.1

      Status: VALIDATED

      Source sequence(s)
      AC026979, EU518495
      Consensus CDS
      CCDS47835.1
      UniProtKB/Swiss-Prot
      B1Q003, Q96T53
      UniProtKB/TrEMBL
      E7DVW7
      Related
      ENSP00000314196.3, ENST00000320542.4
      Conserved Domains (1) summary
      cl00738
      Location:18427
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30131671..30144665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      30410588..30423543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)