FLX1 flavin adenine dinucleotide transporter FLX1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FLX1
Official Full Name: flavin adenine dinucleotide transporter FLX1
Primary source: SGD:S000001396
Locus tag: YIL134W
See related: AllianceGenome:SGD:S000001396; FungiDB:YIL134W; VEuPathDB:YIL134W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables FAD transmembrane transporter activity. Involved in FAD transport. Located in mitochondrion. Used to study multiple acyl-CoA dehydrogenase deficiency. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FLX1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (97395..98330)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A decrease in the amount of Sdh1p in the flx1Delta mutant strain has been determined to be due to a post-transcriptional control that involves regulatory sequences located upstream of the SDH1 coding sequence.
Title: Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae--involvement of the mitochondrial FAD transporter, Flx1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables FAD transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables folic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in FAD transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in FAD transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in folate import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: flavin adenine dinucleotide transporter FLX1

NP_012132.3

Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

97395..98330

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179482.3 → NP_012132.3 TPA: flavin adenine dinucleotide transporter FLX1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012132.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVF3, P40464

UniProtKB/TrEMBL

E9P9B0, G2WG17

Conserved Domains (1) summary

pfam00153
Location:122 → 215

Mito_carr; Mitochondrial carrier protein