SMC4 condensin subunit SMC4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SMC4
Official Full Name: condensin subunit SMC4
Primary source: SGD:S000004076
Locus tag: YLR086W
See related: AllianceGenome:SGD:S000004076; FungiDB:YLR086W; VEuPathDB:YLR086W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin binding activity. Contributes to ATP hydrolysis activity. Involved in mitotic chromosome condensation; rDNA chromatin condensation; and tRNA gene clustering. Located in nucleus. Part of condensin complex. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SMC4 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (302243..306499)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Title: Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Biochemical analyses indicate that inactivation of Smc4 ATPase activity can result in cell lethality because it favors a specific configuration of condensin that locks ATP in the enzyme.
Title: Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.
S. cerevisiae Smc2-Smc4 dimers adopt a variety of conformations.
Title: Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.
Individual contribution of condensin binding sites in securing mitotic stability of the minichromosomes.
Title: [Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model].
Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling
Title: The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling.
The SMC4 is involved in several aspects of chromatin dynamics and DNA recombitional repair.
Title: Multiple roles of Condensins: a complex story.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA gene clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: condensin subunit SMC4

NP_013187.1

Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

302243..306499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181973.1 → NP_013187.1 TPA: condensin subunit SMC4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013187.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY86, Q12267

UniProtKB/TrEMBL

G2WIS8

Conserved Domains (1) summary

COG1196
Location:154 → 1418

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]