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    CARD19 caspase recruitment domain family member 19 [ Homo sapiens (human) ]

    Gene ID: 84270, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CARD19provided by HGNC
    Official Full Name
    caspase recruitment domain family member 19provided by HGNC
    Primary source
    HGNC:HGNC:28148
    See related
    Ensembl:ENSG00000165233 MIM:617726; AllianceGenome:HGNC:28148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BinCARD; C9orf89
    Summary
    Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.5), testis (RPKM 6.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CARD19 in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93096217..93113283)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105262835..105279901)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95858499..95875565)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95821078-95822058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95822059-95823039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95824548-95825115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28611 Neighboring gene sushi domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 12079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95844809-95845437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95852051-95852551 Neighboring gene uncharacterized LOC101927993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95869787-95870287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95875683-95876631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95876632-95877579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95881665-95882481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95882482-95883297 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:95887196-95887360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95888965-95889616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28616 Neighboring gene ninjurin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95893060-95893658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95893659-95894256 Neighboring gene uncharacterized LOC124902212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95897247-95897843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95905234-95906106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95906107-95906979 Neighboring gene Sharpr-MPRA regulatory region 13679 Neighboring gene uncharacterized LOC124902213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Chen KE, et al. Acta Crystallogr D Biol Crystallogr, 2013 May. PMID 23633586
    2. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. Woo HN, et al. FEBS Lett, 2004 Dec 17. PMID 15637807
    3. CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement. Rios KE, et al. Cell Immunol, 2020 Oct. PMID 32763502, Free PMC Article
    4. BinCARD2 as a positive regulator of interferon response in innate immunity. Suzuki H, et al. Biochem Biophys Res Commun, 2019 Apr 2. PMID 30795865
    5. Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy. Wang X, et al. Cell Mol Immunol, 2022 Oct. PMID 36056146, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-kappaB activation after TCR engagement.
      Title: CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement.
    2. BinCARD isoform2 (BinCARD2) is a one of CARD proteins involved in apoptosis and inflammation. BinCARD2 knock down suppresses innate immune responses induced by 3pRNA, poly(I:C) and vesicular stomatitis virus (VSV).
      Title: BinCARD2 as a positive regulator of interferon response in innate immunity.
    3. the crystal structure of BinCARD reveals that all three cysteines were oxidized
      Title: The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized.
    4. BinCard inhibits BCL10-mediated activation of NF-kappa B.
      Title: Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11115, MGC110898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CARD domain binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 19
    Names
    Bcl10-interacting protein with CARD
    bcl10-interacting CARD protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318010.2 → NP_001304939.1  caspase recruitment domain-containing protein 19 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks two alternate exons in the coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL451065, DB550397, DN998463, HY005780
      Conserved Domains (1) summary
      cl14633
      Location:10 → 50
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. NM_001318011.2 → NP_001304940.1  caspase recruitment domain-containing protein 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AA804861, BM930683, HY005780
      Related
      ENST00000468781.5
      Conserved Domains (1) summary
      cd13785
      Location:10 → 95
      CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

    3. NM_032310.5 → NP_115686.3  caspase recruitment domain-containing protein 19 isoform 1

      See identical proteins and their annotated locations for NP_115686.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL451065, BC004500, DB550397, HY005780
      Consensus CDS
      CCDS6702.2
      Related
      ENSP00000364613.2, ENST00000375464.7
      Conserved Domains (1) summary
      cd13785
      Location:10 → 95
      CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

    RNA

    1. NR_134464.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK091611, AL451065, BC038856, DB550397, HY005780

    2. NR_134465.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL451065, BC038856, DB550397, HY005780
      Related
      ENST00000466409.1

    3. NR_134466.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL451065, BC091476, DB550397, HY005780
      Related
      ENST00000490488.5

    4. NR_134467.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA804861, BC004500, BX354102, HY005780

    5. NR_134468.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA804861, CD676329, HY005780

    6. NR_160511.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL451065

    7. NR_160512.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL451065

    8. NR_160513.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL451065

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      93096217..93113283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007061361.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      105262835..105279901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363983.1 → XP_054219958.1  caspase recruitment domain-containing protein 19 isoform X1

    RNA

    1. XR_008488080.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LW7.1 GenPept UniProtKB/Swiss-Prot:Q96LW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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