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    MSE1 glutamate--tRNA ligase MSE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854124, updated on 9-Dec-2024

    Summary

    Official Symbol
    MSE1
    Official Full Name
    glutamate--tRNA ligase MSE1
    Primary source
    SGD:S000005393
    Locus tag
    YOL033W
    See related
    AllianceGenome:SGD:S000005393; FungiDB:YOL033W; VEuPathDB:YOL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glutamate-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MSE1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (263475..265085)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA repair ATPase SMC5 Neighboring gene Opi10p Neighboring gene Sil1p

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables RNA binding  
    enables aminoacyl-tRNA ligase activity  
    enables glutamate-tRNA ligase activity  
    enables glutamate-tRNA ligase activity  
    enables glutamate-tRNA ligase activity PubMed 
    enables tRNA binding  
    enables zinc ion binding  
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    glutamate--tRNA ligase MSE1
    NP_014609.1
    • Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      263475..265085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183287.1 → NP_014609.1  TPA: glutamate--tRNA ligase MSE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W232, P48525, Q08203
      UniProtKB/TrEMBL
      A6ZNH4, B3LJ24, C7GK03, C8ZHT1, N1NVP7
      Conserved Domains (1) summary
      TIGR00464
      Location:44 → 533
      gltX_bact; glutamyl-tRNA synthetase, bacterial family
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