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    Map3k8 mitogen-activated protein kinase kinase kinase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116596, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Map3k8provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 8provided by RGD
    Primary source
    RGD:620969
    See related
    EnsemblRapid:ENSRNOG00000016378 AllianceGenome:RGD:620969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpl2; Tpl-2; D17TPL2
    Summary
    Enables MAP kinase kinase kinase activity. Involved in cardiac ventricle development and gap junction-mediated intercellular transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 108.2), Lung (RPKM 65.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k8 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58078175..58098455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53382908..53403216)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56109403..56129925)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097757 Neighboring gene uncharacterized LOC134482858 Neighboring gene mitochondrial poly(A) polymerase Neighboring gene ribosomal protein L27A like 1 Neighboring gene lysozyme-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Lai DW, et al. Circ Res, 2017 Sep 1. PMID 28724746
    2. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Patriotis C, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 7681591, Free PMC Article
    3. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. Makris A, et al. J Virol, 1993 Jul. PMID 8510223, Free PMC Article
    4. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Sourvinos G, et al. Oncogene, 1999 Sep 2. PMID 10490831
    5. Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Chikamatsu S, et al. Mol Immunol, 2007 Mar. PMID 17049604

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This finding gives a new insight into the role of Cot in the FcvarepsilonRI-mediated NF-kappaB activation in mast cells.
      Title: Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac ventricle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in gap junction-mediated intercellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 8
    Names
    serine/threonine kinase (Tpl-2)
    tumor progression locus 2
    NP_446299.2
    XP_006254110.2
    XP_038951219.1
    XP_038951221.1
    XP_038951222.1
    XP_063132092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053847.2 → NP_446299.2  mitogen-activated protein kinase kinase kinase 8

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q63562
      UniProtKB/TrEMBL
      A6K9G3
      Conserved Domains (1) summary
      cd13995
      Location:133 → 388
      STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      58078175..58098455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276022.1 → XP_063132092.1  mitogen-activated protein kinase kinase kinase 8 isoform X4

    2. XM_006254048.3 → XP_006254110.2  mitogen-activated protein kinase kinase kinase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q63562
      UniProtKB/TrEMBL
      A6K9G3
      Related
      ENSRNOP00000022190.2, ENSRNOT00000022190.5
      Conserved Domains (1) summary
      cd13995
      Location:133 → 388
      STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

    3. XM_039095293.2 → XP_038951221.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:2 → 231
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039095291.2 → XP_038951219.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:2 → 231
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039095294.2 → XP_038951222.1  mitogen-activated protein kinase kinase kinase 8 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 182
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63562.1 GenPept UniProtKB/Swiss-Prot:Q63562

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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