Adgrv1 adhesion G protein-coupled receptor V1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrv1provided by RGD
Official Full Name: adhesion G protein-coupled receptor V1provided by RGD
Primary source: RGD:1562101
See related: EnsemblRapid:ENSRNOG00000016306 AllianceGenome:RGD:1562101
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr98; RGD1562101
Summary: Predicted to enable several functions, including G-protein alpha-subunit binding activity; adenylate cyclase inhibitor activity; and calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of adenylate cyclase activity; photoreceptor cell maintenance; and positive regulation of protein kinase C signaling. Predicted to act upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; and positive regulation of protein kinase A signaling. Located in stereocilium. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 46.1), Brain (RPKM 22.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 91

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (13067149..13647407, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (11331434..11911713, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (8926843..9504455, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142501 (e-PCR)
- UniSTS:231748

RH135421 (e-PCR)
- UniSTS:218698

D2Rat1 (e-PCR)
- UniSTS:118650

D2Rat368 (e-PCR), detects polymorphism
- UniSTS:227502

UniSTS:234165 (e-PCR)
- UniSTS:234165

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables myosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of animal organ identity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
involved_in nervous system process	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of light stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of USH2 complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in periciliary membrane compartment	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in stereocilia ankle link	ISO Inferred from Sequence Orthology more info
part_of stereocilia ankle link complex	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in stereocilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor V1; adhesion G-protein coupled receptor V1

Names: G protein-coupled receptor 98; neurepin; very large G protein-coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

13067149..13647407 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103389.2 → XP_038959317.1 adhesion G-protein coupled receptor V1 isoform X1

UniProtKB/TrEMBL

A0A096MK89

Conserved Domains (7) summary

TIGR00845
Location:4160 → 4493

caca; sodium/calcium exchanger 1

pfam03736
Location:3402 → 3434

EPTP; EPTP domain

pfam13385
Location:1351 → 1500

Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

cd14964
Location:5940 → 5962

7tm_GPCRs; TM helix 2 [structural motif]

cl02522
Location:1733 → 1813

Calx-beta; Calx-beta domain

cl02559
Location:5854 → 5900

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:5921 → 6161

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039103390.2 → XP_038959318.1 adhesion G-protein coupled receptor V1 isoform X2

UniProtKB/TrEMBL

A0A096MK89

Related

ENSRNOP00000068422.1, ENSRNOT00000076996.4

Conserved Domains (7) summary

TIGR00845
Location:4149 → 4482

caca; sodium/calcium exchanger 1

pfam03736
Location:3391 → 3423

EPTP; EPTP domain

pfam13385
Location:1340 → 1489

Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

cd14964
Location:5929 → 5951

7tm_GPCRs; TM helix 2 [structural motif]

cl02522
Location:1722 → 1802

Calx-beta; Calx-beta domain

cl02559
Location:5843 → 5889

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:5910 → 6150

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039103391.2 → XP_038959319.1 adhesion G-protein coupled receptor V1 isoform X3

Conserved Domains (6) summary

TIGR00845
Location:1861 → 2194

caca; sodium/calcium exchanger 1

pfam03736
Location:1103 → 1135

EPTP; EPTP domain

cd14964
Location:3641 → 3663

7tm_GPCRs; TM helix 2 [structural motif]

cl02522
Location:2708 → 2800

Calx-beta; Calx-beta domain

cl02559
Location:3555 → 3601

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:3622 → 3862

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily