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    Zfp385b zinc finger protein 385B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311137, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp385bprovided by RGD
    Official Full Name
    zinc finger protein 385Bprovided by RGD
    Primary source
    RGD:1311181
    See related
    EnsemblRapid:ENSRNOG00000019065 AllianceGenome:RGD:1311181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp533
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in nucleus. Orthologous to human ZNF385B (zinc finger protein 385B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 143.9), Brain (RPKM 36.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp385b in Genome Data Viewer
    Location:
    3q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (82762387..83140856, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (62355182..62640417, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (64269817..64556084, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486392 Neighboring gene uncharacterized LOC134486391 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 20 Neighboring gene uncharacterized LOC134486393 Neighboring gene uncharacterized LOC134486395 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC120101584 Neighboring gene uncharacterized LOC134486394 Neighboring gene uncharacterized LOC134486396 Neighboring gene CWC22 spliceosome associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. Iijima K, et al. Eur J Immunol, 2012 Dec. PMID 22945289
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 385B
    Names
    zinc finger protein 533

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107736.3 → NP_001101206.1  zinc finger protein 385B isoform c

      See identical proteins and their annotated locations for NP_001101206.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K4A6, A6HMJ4, D3ZHY2
      Related
      ENSRNOP00000025803.5, ENSRNOT00000025803.8
      Conserved Domains (2) summary
      sd00020
      Location:211 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:273 → 296
      zf-met; Zinc-finger of C2H2 type

    2. NM_001433354.1 → NP_001420283.1  zinc finger protein 385B isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001433355.1 → NP_001420284.1  zinc finger protein 385B isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y545, A6HMJ3

    4. NM_001433357.1 → NP_001420286.1  zinc finger protein 385B isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001433358.1 → NP_001420287.1  zinc finger protein 385B isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZTA2

    6. NM_001433359.1 → NP_001420288.1  zinc finger protein 385B isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZTA2

    7. NM_001433360.1 → NP_001420289.1  zinc finger protein 385B isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMJ5

    8. NM_001433361.1 → NP_001420290.1  zinc finger protein 385B isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMJ5

    9. NM_001433362.1 → NP_001420291.1  zinc finger protein 385B isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      82762387..83140856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591701.3 → XP_017447190.1  zinc finger protein 385B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4A6

    2. XM_017591702.3 → XP_017447191.1  zinc finger protein 385B isoform X3

      Conserved Domains (3) summary
      smart00451
      Location:35 → 65
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:301 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:363 → 386
      zf-met; Zinc-finger of C2H2 type

    3. XM_063283636.1 → XP_063139706.1  zinc finger protein 385B isoform X4

    4. XM_017591700.3 → XP_017447189.1  zinc finger protein 385B isoform X1

      Related
      ENSRNOP00000076914.2, ENSRNOT00000118734.2

    5. XM_063283637.1 → XP_063139707.1  zinc finger protein 385B isoform X4

    6. XM_017591703.3 → XP_017447192.1  zinc finger protein 385B isoform X9

      UniProtKB/TrEMBL
      A0A0G2K4A6

    7. XM_063283640.1 → XP_063139710.1  zinc finger protein 385B isoform X11

    8. XM_039104863.2 → XP_038960791.1  zinc finger protein 385B isoform X10

      UniProtKB/TrEMBL
      A0A0G2K4A6, A0A8I6G493
      Conserved Domains (2) summary
      sd00020
      Location:219 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:280 → 304
      zf-met; Zinc-finger of C2H2 type

    9. XM_063283642.1 → XP_063139712.1  zinc finger protein 385B isoform X13

    10. XM_063283639.1 → XP_063139709.1  zinc finger protein 385B isoform X8

      Related
      ENSRNOP00000080212.2, ENSRNOT00000104251.2

    11. XM_039104861.2 → XP_038960789.1  zinc finger protein 385B isoform X6

      UniProtKB/TrEMBL
      A0A0G2K4A6
      Conserved Domains (2) summary
      sd00020
      Location:262 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:323 → 347
      zf-met; Zinc-finger of C2H2 type

    12. XM_039104864.2 → XP_038960792.1  zinc finger protein 385B isoform X5

      Conserved Domains (2) summary
      sd00020
      Location:198 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:259 → 283
      zf-met; Zinc-finger of C2H2 type

    13. XM_063283641.1 → XP_063139711.1  zinc finger protein 385B isoform X12

    14. XM_039104865.2 → XP_038960793.1  zinc finger protein 385B isoform X5

      Conserved Domains (2) summary
      sd00020
      Location:198 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:259 → 283
      zf-met; Zinc-finger of C2H2 type

    15. XM_063283638.1 → XP_063139708.1  zinc finger protein 385B isoform X7

    16. XM_039104860.2 → XP_038960788.1  zinc finger protein 385B isoform X5

      UniProtKB/TrEMBL
      A0A0G2K4A6, A0A8I5ZTA2
      Related
      ENSRNOP00000072967.3, ENSRNOT00000089065.3
      Conserved Domains (2) summary
      sd00020
      Location:198 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:259 → 283
      zf-met; Zinc-finger of C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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